Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

Abstract: Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to ?4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results:H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag? showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.

 Fuente: Front Microbiol. 2017 May 29;8:888

Editorial: Frontiers Research Foundation

 Fecha de publicación: 29/05/2017

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fmicb.2017.00888

ISSN: 1664-302X

Autores/as

FERNÁNDEZ DE LARREA BAZ, NEREA

MICHEL, ANGELIKA

ROMERO, BEATRIZ

PÉREZ GÓMEZ, BEATRIZ

MORENO, VICTOR

MARTÍN, VICENTE

JOSE JUAN JIMENEZ MOLEON

CASTILLA, JESÚS

TARDÓN, ADONINA

RUIZ, IRUNE

PEIRÓ, ROSANA

TEJADA, ANTONIO

CHIRLAQUE, MARÍA D.

BUTT, JULIA A.

OLMEDO REQUENA, ROCÍO

LINARES, PEDRO

BOLDO, ELENA

CASTELLS, ANTONI