Abstract: A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.
Fuente: Sci Rep. 2017 Jan 6;7:40303
Editorial: Nature Publishing Group
Fecha de publicación: 06/01/2017
Nº de páginas: 6
Tipo de publicación: Artículo de Revista
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LÓPEZ MEJÍAS, RAQUEL
ALFONSO FERNANDO CORRALES MARTINEZ
ROBUSTILLO VILLARINO, MONTSERRAT
GONZÁLEZ JUANATEY, CARLOS
FRANCISCO JAVIER LLORCA DIAZ
REMUZGO MARTÍNEZ, SARA
TRINIDAD DIERSSEN SOTOS
MIRANDA FILLOY, JOSÉ A.
RAMÍREZ HUARANGA, MARCO A.
PINA MURCIA, TRINITARIO
RICARDO BLANCO ALONSO
ALEGRE SANCHO, JUAN J.
VERONICA MIJARES DIAZ
BEGOÑA UBILLA GARCIA
FERRAZ AMARO, IVÁN
JAVIER GONZALO OCEJO VIÑALS
MIGUEL ANGEL GONZALEZ-GAY MANTECON