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Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis

Abstract: A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Sci Rep. 2017 Jan 6;7:40303

Editorial: Nature Publishing Group

 Fecha de publicación: 06/01/2017

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/srep40303

ISSN: 2045-2322

Autores/as

LÓPEZ MEJÍAS, RAQUEL

ALFONSO FERNANDO CORRALES MARTINEZ

VICENTE, ESTHER

ROBUSTILLO VILLARINO, MONTSERRAT

GONZÁLEZ JUANATEY, CARLOS

FERNANDA GENRE

REMUZGO MARTÍNEZ, SARA

MIRANDA FILLOY, JOSÉ A.

RAMÍREZ HUARANGA, MARCO A.

PINA MURCIA, TRINITARIO

RICARDO BLANCO ALONSO

ALEGRE SANCHO, JUAN J.

RAYA, ENRIQUE

VERONICA MIJARES DIAZ

BEGOÑA UBILLA GARCIA

FERRAZ AMARO, IVÁN

JAVIER GONZALO OCEJO VIÑALS