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Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study

Abstract: Colorectal cancer (CRC) screening of the average risk population is only indicated according to age. We aim to elaborate a model to stratify the risk of CRC by incorporating environmental data and single nucleotide polymorphisms (SNP). The MCC-Spain case-control study included 1336 CRC cases and 2744 controls. Subjects were interviewed on lifestyle factors, family and medical history. Twenty-one CRC susceptibility SNPs were genotyped. The environmental risk model, which included alcohol consumption, obesity, physical activity, red meat and vegetable consumption, and nonsteroidal anti-inflammatory drug use, contributed to CRC with an average per factor OR of 1.36 (95% CI 1.27 to 1.45). Family history of CRC contributed an OR of 2.25 (95% CI 1.87 to 2.72), and each additional SNP contributed an OR of 1.07 (95% CI 1.04 to 1.10). The risk of subjects with more than 25 risk alleles (5th quintile) was 82% higher (OR 1.82, 95% CI 1.11 to 2.98) than subjects with less than 19 alleles (1st quintile). This risk model, with an AUROC curve of 0.63 (95% CI 0.60 to 0.66), could be useful to stratify individuals. Environmental factors had more weight than the genetic score, which should be considered to encourage patients to achieve a healthier lifestyle.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Sci Rep. 2017 Feb 24;7:43263

Editorial: Nature Publishing Group

 Fecha de publicación: 24/02/2017

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/srep43263

ISSN: 2045-2322

Autores/as

IBÁÑEZ SANZ, GEMMA

DÍEZ VILLANUEVA, ANNA

ALONSO, M. HENAR

RODRÍGUEZ MORANTA, FRANCISCO

PÉREZ GÓMEZ, BEATRIZ

BUSTAMANTE, MARIONA

AMIANO, PILAR

ARDANAZ, EVA

TARDÓN, ADONINA

JOSE JUAN JIMENEZ MOLEON

PEIRÓ, ROSANA

ALGUACIL, JUAN

NAVARRO, CARMEN

GUINÓ, ELISABET

BINEFA, GEMMA

FERNÁNDEZ NAVARRO, PABLO