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Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis

Abstract: Several protein tyrosine phosphatase non-receptor 22 (PTPN22) single-nucleotide polymorphisms (SNPs) have been significantly related with rheumatoid arthritis (RA) susceptibility. Nevertheless, its potential influence on PTPN22 expression in RA has not been completely elucidated. Furthermore, PTPN22 binds to C-Src tyrosine kinase (CSK) forming a key complex in autoimmunity. However, the information of CSK gene in RA is scarce. In this study, we analyzed the relative PTPN22 and CSK expression in peripheral blood from 89 RA patients and 43 controls to determine if the most relevant PTPN22 (rs2488457, rs2476601 and rs33996649) and CSK (rs34933034 and rs1378942) polymorphisms may influence on PTPN22 and CSK expression in RA. The association between PTPN22 and CSK expression in RA patients and their clinical characteristics was also evaluated. Our study shows for the first time a marked down-regulation of PTPN22 expression in RA patients carrying the risk alleles of PTPN22 rs2488457 and rs2476601 compared to controls (p?=?0.004 and p?=?0.007, respectively). Furthermore, CSK expression was significantly lower in RA patients than in controls (p?

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Scientific Reports 7, Article number: 10525 (2017)

Editorial: Nature Publishing Group

 Año de publicación: 2017

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41598-017-10915-9

ISSN: 2045-2322

Autores/as

REMUZGO MARTÍNEZ, SARA

FERNANDA GENRE

CASTAÑEDA, SANTOS

ALFONSO FERNANDO CORRALES MARTINEZ

MORENO FRESNEDA, PABLO

BEGOÑA UBILLA GARCIA

VERONICA MIJARES DIAZ

PORTILLA, VIRGINIA

GONZÁLEZ VELA, JESÚS

PINA MURCIA, TRINITARI

JAVIER GONZALO OCEJO VIÑALS

IRURE VENTURA, JUAN

RICARDO BLANCO ALONSO

MARTÍN, JAVIER

LÓPEZ MEJÍAS, RAQUEL