Buscar

 Detalle_Publicacion

Optimal parameters for hyperthermia treatment using biomineralized magnetite nanoparticles: theoretical and experimental approach

Abstract: We hereby present experimental and theoretical insights on the use of biomineralized magnetite nanoparticles, called magnetosomes, as heat nanoinductors in the magnetic hyperthermia technique. The heating efficiency or specific absorption rate of magnetosomes extracted from Magnetospirillum gryphiswaldense bacteria and immersed in water and agarose gel, was directly determined from the hysteresis loops obtained at different frequencies and magnetic field amplitudes. We demonstrate that heat production of magnetosomes can be predicted in the framework of the Stoner-Wohlfarth theory of uniaxial magnetic anisotropy subjected to significant dipolar interactions, which can be described in terms of an interaction anisotropy superimposed to that of each particle. Based on these findings, we propose optimal magnetic field amplitude and frequency values in order to maximize the heat production while keeping the undesired eddy current effects below safe and tolerable limits. The efficiency of magnetosomes as heat generators and their impact on cell viability has been checked in macrophage cells. Our results clearly indicate that the hyperthermia treatment causes both cell death and inhibition of cell proliferation. Specifically, only 36% of the treated macrophages remained alive 2 h after alternating magnetic field exposure, and 24 h later the percentage fell to 22%.

 Fuente: Journal of Physical Chemistry C, 2016, 120(42), 24437-24448

Editorial: American Chemical Society

 Fecha de publicación: 03/10/2016

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

DOI: 10.1021/acs.jpcc.6b07321

ISSN: 1932-7447,1932-7455

Proyecto español: MAT2014- 55049-C2-1-R

Proyecto europeo: info:eu-repo/grantAgreement/EC/FP7/604448/EU/Nanometrology Standardization Methods for Magnetic Nanoparticles/NanoMag/

Url de la publicación: https://doi.org/10.1021/acs.jpcc.6b07321

Autores/as

MUELA BLÁZQUEZ, ALICIA

MUÑOZ RODRÍGUEZ, DAVID

ORUE GOICURIA, IÑAKI

GARAIO URABAYEN, ENEKO

ABAD DÍAZ DE CERIO, ANA

GARCÍA MARTÍNEZ, JOSÉ ÁNGEL

FERNÁNDEZ GUBIEDA, MARÍA LUISA