Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Biomarker tools to Design Clinical Vaccines Determined from a study of annual Listeriosis Incidence in Northern spain

Abstract: Two regions of northern Spain, Gipuzkoa, and Cantabria present high annual incidence of listeriosis (1.86 and 1.71 cases per 100,000 inhabitants, respectively). We report that the high annual incidences are a consequence of infection with highly virulent Listeria monocytogenes isolates linked to fatal outcomes in elderly patients with cancer. In addition, listeriosis patients with cancer present low IL-17A/IL-6 ratios and significantly reduced levels of anti-GAPDH1?22 antibodies, identified as two novel biomarkers of poor prognosis. Analysis of these biomarkers may aid in reducing the incidence of listeriosis. Moreover, GAPDH1?22-activated monocyte-derived dendritic cells of listeriosis patients with cancer seem useful tools to prepare clinical vaccines as they produce mainly Th1 cytokines.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Front. Immunol. Nov 2016 7:541

Editorial: Frontiers Research Foundation

 Fecha de publicación: 01/11/2016

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.3389/fimmu.2016.00541

ISSN: 1664-3224

Autores/as

RICARDO CALDERON GONZALEZ

HECTOR TERAN NAVARRO

MARIMON, JOSÉ MARÍA

GONZÁLEZ RICO, CLAUDIA

CALVO MONTES, JORGE

ALKORTA GURRUTXAGA, MIRIAM

LUIS MARTINEZ MARTINEZ

PÉREZ TRALLERO, EMILIO

CARMEN ALVAREZ DOMINGUEZ