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Pure Membranous Lupus Nephritis: Description of a Cohort of 150 Patients and Review of the Literature

Abstract: OBJECTIVES: The course and long-term outcome of pure membranous lupus nephritis (MLN) are little understood. The aims of this study are to evaluate the clinical features, course, outcome and prognostic indicators in pure MLN and to determine the impact of ethnicity and the type of health insurance on the course and prognosis of pure MLN. METHODS: We conducted a retrospective review of medical records of 150 patients with pure MLN from Spain and the USA. RESULTS: Mean age was 34.2±12.5 and 80% were women. Sixty-eight percent of patients had nephrotic syndrome at diagnosis. The average serum creatinine was 0.98±0.78mg/dl. Six percent of patients died and 5.3% developed end-stage renal disease (ESRD). ESRD was predicted by male sex, hypertension, dyslipidemia, high basal 24h-proteinuria, high basal serum creatinine and a low basal creatinine clearance. Age, cardiac insufficiency, peripheral artheriopathy, hemodialysis and not having received mycophenolate mofetil or antimalarials for MLN predicted death. CONCLUSIONS: Pure MLN frequently presents with nephrotic syndrome, high proteinuria and normal serum creatinine. Its prognosis is favourable in maintaining renal function although proteinuria usually persists over time. Baseline cardiovascular disease and not having a health insurance are related with poor prognosis.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Reumatol Clin. 2019 Jan - Feb;15(1):34-42

Editorial: Elsevier España

 Año de publicación: 2019

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.reuma.2017.04.005

ISSN: 1699-258X,1885-1398,1886-3604

Autores/as

SILVA FERNÁNDEZ, LUCÍA

OTÓN, TERESA

ASKANASE, ANCA

CARREIRA, PATRICIA

LÓPEZ LONGO, FRANCISCO JAVIER

OLIVÉ, ALEJANDRO

RÚA FIGUEROA, ÍÑIGO

NARVÁEZ, JAVIER

RUIZ LUCEA, ESTHER

ANDRÉS, MARIANO

CALVO, ENRIQUE

TOYOS, FRANCISCO

ALEGRE SANCHO, JUAN JOSÉ

TOMERO, EVA

MONTILLA, CARLOS

ZEA, ANTONIO

URIARTE, ESTHER

JAIME CALVO ALEN