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Abstract: The definition of anti-HLA antibody profile in highly sensitized patients on a waiting list is crucial when virtual crossmatch is used in organ allocation systems, but also when used to identify the true deleterious anti-HLA antibodies. Here we propose different levels of risk based on the results of anti-HLA antibody testing in neat serum (N) and after sera dilution (DIL) and C1q test in 18 highly sensitized patients. This group was heterogeneous in terms of anti-HLA antibody titers and their ability to fix complement. After dilution, 15 out of 18 patients (83.3%) showed a reduction of positive bead counts whereas 4 patients showed a prozone effect and complement fixation was demonstrated. The high dilution of sera and ascertaining the complement fixation allow the accurate definition of risk anti-HLA antibody profiles in highly sensitized patients, as demonstrated in 5 of the sensitized patients who were transplanted.
Fuente: PLoS One. 2017; 12(2): e0171463
Editorial: Public Library of Science
Año de publicación: 2017
Nº de páginas: 13
Tipo de publicación: Artículo de Revista
DOI: 10.1371/journal.pone.0171463
ISSN: 1932-6203
Consultar en UCrea Leer publicación
IRURE, JUAN
ASENSIO, ESTHER
EMILIO RODRIGO CALABIA
IÑIGO ROMON ALONSO
GÓMEZ, JAVIER
MANUEL ANTONIO ARIAS RODRIGUEZ
MARCOS LOPEZ HOYOS
DAVID SAN SEGUNDO ARRIBAS
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