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Improvement in the definition of anti-HLA antibody profile in highly sensitized patients

Abstract: The definition of anti-HLA antibody profile in highly sensitized patients on a waiting list is crucial when virtual crossmatch is used in organ allocation systems, but also when used to identify the true deleterious anti-HLA antibodies. Here we propose different levels of risk based on the results of anti-HLA antibody testing in neat serum (N) and after sera dilution (DIL) and C1q test in 18 highly sensitized patients. This group was heterogeneous in terms of anti-HLA antibody titers and their ability to fix complement. After dilution, 15 out of 18 patients (83.3%) showed a reduction of positive bead counts whereas 4 patients showed a prozone effect and complement fixation was demonstrated. The high dilution of sera and ascertaining the complement fixation allow the accurate definition of risk anti-HLA antibody profiles in highly sensitized patients, as demonstrated in 5 of the sensitized patients who were transplanted.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: PLoS One. 2017; 12(2): e0171463

Editorial: Public Library of Science

 Año de publicación: 2017

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1371/journal.pone.0171463

ISSN: 1932-6203

Autores/as

IRURE, JUAN

ASENSIO, ESTHER

EMILIO RODRIGO CALABIA

IÑIGO ROMON ALONSO

GÓMEZ, JAVIER

MANUEL ANTONIO ARIAS RODRIGUEZ

DAVID SAN SEGUNDO ARRIBAS