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 Detalle_Publicacion

Protective Role of the Interleukin 33 rs3939286 Gene Polymorphism in the Development of Subclinical Atherosclerosis in Rheumatoid Arthritis Patients

Abstract: OBJECTIVES: To determine whether the interleukin-33 (IL-33)-interleukin-1 receptor like 1 (IL-1RL1) signaling pathway is implicated in the risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). METHODS: A total of 576 Spanish RA patients from Northern Spain were genotyped for 6 well-known IL33-IL1RL1 polymorphisms (IL33 rs3939286, IL33 rs7025417, IL33 rs7044343, IL1RL1 rs2058660, IL1RL1 rs2310173 and IL1RL1 rs13015714) by TaqMan genotyping assay. The presence of subclinical atherosclerosis was determined by the assessment of carotid intima-media thickness (cIMT) by carotid ultrasound (US). RESULTS: RA patients carrying the TT genotype of the IL33 rs3939286 polymorphism had lower cIMT values than those homozygous for the CC genotype (mean ± standard deviation (SD): 0.71 ± 0.14 mm versus 0.76 ± 0.16 mm, respectively) while patients carrying the CT genotype had intermediate cIMT values (mean ± SD: 0.73 ± 0.17 mm). Moreover, RA patients carrying the mutant allele T of the IL33 rs3939286 polymorphism exhibited significantly lower cIMT values than those carrying the wild allele C (mean ± SD: 0.72 ± 0.16 mm versus 0.75 ± 0.18 mm respectively; p = 0.04). The association of both genotype and allele frequencies of IL33 rs3939286 and cIMT levels remained statistically significant after adjustment for sex, age at the time of US study, follow-up and center (p = 0.006 and p = 0.0023, respectively), evidencing that the potential effect conferred by IL33 rs3939286 may be independent of confounder factors. No association with other IL33-IL1RL1 genetic variants was observed. CONCLUSIONS: In conclusion, our results may suggest a potential protective effect of the IL33 rs3939286 allele T in the risk of subclinical atherosclerosis in patients with RA.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: PLoS One. 2015 Nov 16;10(11):e0143153

Editorial: Public Library of Science

 Año de publicación: 2015

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1371/journal.pone.0143153

ISSN: 1932-6203

Autores/as

LÓPEZ MEJÍAS, R

GENRE, FERNANDA

REMUZGO MARTÍNEZ, S

ROBUSTILLO VILLARINO, M

GARCÍA BERMÚDEZ, M

CORRALES, A

GONZÁLEZ JUANATEY, CARLOS

UBILLA GARCÍA, BEGOÑA

MIRANDA FILLOY, JA

MIJARES DÍAZ, VERÓNICA

PINA, T

BLANCO, R

ALEGRE SANCHO, JJ

RAMÍREZ HUARANGA, MA

MINGUEZ SÁNCHEZ, MD

TEJERA SEGURA, B

FERRAZ AMARO, I

VICENTE, E

CARMONA, FD

CASTAÑEDA, S

MARTÍN, J