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Novel genetic loci associated with hippocampal volume

Abstract: The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer?s disease (rg¼ 0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Nat Commun. 2017 Jan 18;8:13624

Editorial: Nature Publishing Group

 Año de publicación: 2017

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/ncomms13624

ISSN: 2041-1723

Url de la publicación: https://dx.doi.org/10.1038/ncomms13624

Autores/as

HIBAR, DERREK P.

ADAMS, HIEAB H.H.

JAHANSHAD, NEDA

CHAUHAN, GANESH

STEIN, JASON L.

HOFER, EDITH

RENTERIA, MIGUEL E.

BIS, JOSHUA C.

ARIAS VASQUEZ, ALEJANDRO

KAMRAN IKRAM, M.

DESRIVIERES, SYLVANE

VERNOOIJ, MEIKE W.

ABRAMOVIC, LUCIJA

ALHUSAINI, SAUD

AMIN, NAJAF

ANDERSSON, MICAEL

ARFANAKIS, KONSTANTINOS

ARIBISALA, BENJAMIN S.

ROBERTO ROIZ SANTIAÑEZ