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 Detalle_Publicacion

Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients

Abstract: OBJECTIVE: Interstitial lung disease (ILD) is one of the most serious complications of rheumatoid arthritis (RA). In the present study, we aimed to assess the efficacy of abatacept (ABA) in patients with ILD associated to RA. METHODS: National multicenter, non-controlled, open-label registry study of RA patients with ILD treated with ABA. RESULTS: 63 patients (36 women) with RA-associated ILD undergoing ABA therapy were studied. The mean ± standard deviation age at the time of the study was 63.2 ± 9.8 years. The median duration of RA and ILD from diagnosis were 6.8 and 1 year, respectively. RA was seropositive in 55 patients (87.3%). In 15 (23.8%) of 63 patients the development of ILD was closely related to the administration of synthetic or biologic disease modifying anti-rheumatic drugs. After a follow-up of 9.4 ± 3.2 months, two-thirds of patients remained stable whereas one-quarter experienced improvement in the Modified Medical Research Council scale. At that time forced vital capacity remained stable in almost two-thirds of patents and improved in one out of five patients assessed. Also, diffusing capacity of the lung for carbon monoxide remained stable in almost two-thirds and showed improvement in a quarter of the patients assessed. At 12 months, 50% of the 22 patients in whom chest HRCT scan was performed due persistence of respiratory symptoms showed stabilization, 8 (36.4%) improvement and 3 worsening of the HRCT scan pattern. Eleven of 63 patients had to discontinue ABA, mainly due to adverse events. CONCLUSION: ABA appears to be an effective in RA-associated ILD.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Semin Arthritis Rheum. 2018 Aug;48(1):22-27

Editorial: Elsevier

 Fecha de publicación: 01/08/2018

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2017.12.012

ISSN: 0049-0172,1532-866X

Url de la publicación: https://dx.doi.org/10.1016/j.semarthrit.2017.12.012

Autores/as

FERNÁNDEZ DÍAZ, CARLOS

JAVIER LORICERA GARCIA

CASTAÑEDA, SANTOS

LÓPEZ MEJÍAS, RAQUEL

OJEDA GARCIA, CLARA

OLIVÉ, ALEJANDRO

RODRÍGUEZ MUGURUZA, SAMANTHA

CARREIRA, PATRICIA E.

PÉREZ SANDOVAL, TRINIDAD

RETUERTO, MIRIAM

CERVANTES PÉREZ, EVELIN C.

FLORES ROBLES, BRYAN J.

HERNÁNDEZ CRUZ, BLANCA

URRUTICOECHEA, ANA

VÍCTOR MANUEL MORA CUESTA

PALMOU FONTANA, NATALIA

RICARDO BLANCO ALONSO