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Altered secretion patterns of proinflammatory adipokines may influence the increased risk of cardiovascular mortality observed in patients with chronic inflammatory diseases.
To determine whether two adipokines, leptin and resistin, correlate with metabolic syndrome features and disease severity in psoriatic patients who underwent anti-TNF-a therapy.
Prospective study of consecutive non-diabetic patients with moderate-to-severe psoriasis who completed 6 months of therapy with anti-TNF-a- adalimumab. Patients with kidney disease, hypertension or body mass index =35 Kg/m(2) were excluded. Metabolic and clinical evaluation was performed at the onset of anti-TNF-a treatment and at month 6.
Twenty-nine patients were assessed. A correlation between adiposity and leptin was observed (waist circumference and leptin levels after 6 months of therapy: r = 0.43; P = 0.030). Leptin concentration also correlated with blood pressure before adalimumab onset (systolic: r = 0.48; P = 0.013 and diastolic blood pressure: r = 0.50; P = 0.010 ). A marginally significant negative correlation between insulin sensitivity (QUICKI) and leptin levels was also observed. CRP levels correlated with leptin prior to the onset of adalimumab (r = 0.45; P = 0.020) and with resistin both before (r = 0.45; P = 0.020) and after 6 months of therapy (r = 0.55; P = 0.004). A positive association between parameters of disease activity such as BSA (r = 0.60; P = 0.001) and PASI (r = 0.63; P = 0.001) prior to the onset of adalimumab therapy and resistin concentrations was also disclosed. No significant changes in leptin and resistin concentrations following the 6-month treatment with adalimumab were seen.
In patients with moderate-to-severe psoriasis leptin correlates with metabolic syndrome features and inflammation whereas resistin correlate with inflammation and disease severity.
Fuente: J Eur Acad Dermatol Venereol 2015 Oct;29(10):1995-2001
Editorial: Blackwell Publishing Ltd
Año de publicación: 2015
Nº de páginas: 7
Tipo de publicación: Artículo de Revista
LÓPEZ MEJÍAS, R
ARMESTO ALONSO, SUSANA
UBILLA GARCÍA, BEGOÑA
MIJARES DÍAZ, VERÓNICA
TRINIDAD DIERSSEN SOTOS
MARCOS ANTONIO GONZALEZ LOPEZ
JOSE LUIS HERNANDEZ HERNANDEZ
FRANCISCO JAVIER LLORCA DIAZ
MIGUEL ANGEL GONZALEZ-GAY MANTECON
MARIA CARMEN GONZALEZ VELA