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HLA-DRB1 association with Henoch-Schonlein purpura

Abstract: Objective: Henoch-Schönlein purpura (HSP) is the most common vasculitis in children but it is not exceptional in adults. Increased familial occurrence supports a genetic predisposition for HSP. In this context, an association with the human leukocyte antigen-HLA-DRB1*01 phenotype has been suggested in Caucasian individuals with HSP. However, data on the potential association of HSP with HLA-DRB1*01 were based on small case series. To further investigate this issue, we performed HLA-DRB1 genotyping of the largest series of HSP patients ever assessed for genetic studies in Caucasians. Methods: 342 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al classification criteria, and 303 sex and ethnically matched controls were assessed. HLA-DRB1 alleles were determined using a PCR-Sequence-Specific-Oligonucleotide Probe (PCR-SSOP) method. Results: A statistically significant increase of HLA-DRB1*01 in HSP patients when compared with controls was found (43% vs 7%, respectively; p<0.001; odds ratio-OR=2.03 [1.43-2.87]). It was due to the increased frequency of HLA-DRB1*0103 phenotype in HSP (14% vs 2%; p<0.001; OR=8.27 [3.46-23.9]). These results remained statistically significant after adjusting for Bonferroni correction. In contrast, a statistically significant decreased frequency of the HLA-DRB1*0301 phenotype was observed in patients compared to controls (5.6% vs 18.1%, respectively; p<0.001, OR=0.26 [0.14-0.47]), even after adjustment for Bonferroni correction. No HLA-DRB1 association with specific features of the disease was found. Conclusion: Our study confirms an association of HSP with HLA-DRB1*01 in Caucasians. Also, a protective effect against the development of HSP appears to exist in Caucasians carrying the HLA-DRB1*03 phenotype.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Arthritis and rheumatology Vol. 67, No. 3, March 2015, pp 823–827

Editorial: John Wiley and Sons Ltd

 Año de publicación: 2014

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1002/art.38979

ISSN: 2326-5205,2326-5191

Url de la publicación: http://dx.doi.org/10.1002/art.38979

Autores/as

LÓPEZ MEJÍAS, RAQUEL

FERNANDA GENRE

PÉREZ, BS

CASTAÑEDA, S

ORTEGO CENTENO, N

UBILLA GARCÍA, BEGOÑA

REMUZGO MARTÍNEZ, S

VERONICA MIJARES DIAZ

PINA MURCIA, TRINITARI

CALVO RÍO, V

MÁRQUEZ, A

SALA, ICARDO

MIRANDA FILLOY, JA

CONDE JALDÓN, M

ORTÍZ FERNÁNDEZ, L

RUBIO, E

LEÓN LUQUE, M

BLANCO MADRIGAL, JM

GALÍNDEZ AGUIRREGOIKOA, E

JAVIER GONZALO OCEJO VIÑALS

GONZÁLEZ ESCRIBANO, F

MARTÍN, J

RICARDO BLANCO ALONSO