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 Detalle_Publicacion

MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production

Abstract: Parathyroid hormone (PTH) affects the skeleton by acting on osteocytes (Ots) in bone through yet unclear mechanisms. We report that matrix metalloproteinase 14 (MMP14) expression/activity are increased in bones from mice with genetic constitutive activation (ca) of the PTH receptor 1 (PTH1R) in Ots (caPTH1ROt) and in bones from mice exposed to elevated PTH levels but not in mice lacking [conditional knockout (cKO)] the PTH1R in Ots (cKOPTH1ROt). Furthermore, PTH upregulates MMP14 in human bone cultures and in Ot-enriched bones from floxed control mice but not from cKOPTH1ROt mice. MMP14 activity increases soluble receptor activator of NF-?? ligand production, which in turn, stimulates osteoclast differentiation and resorption. Pharmacologic inhibition of MMP14 activity reduced the high bone remodeling exhibited by caPTH1ROt mice or induced by chronic PTH elevation and decreased bone resorption but allowed full stimulation of bone formation induced by PTH injections, thereby potentiating bone gain. Thus, MMP14 is a new member of the intricate gene network activated in Ots by PTH1R signaling that can be targeted to adjust the skeletal responses to PTH in favor of bone preservation.-Delgado-Calle, J., Hancock, B., Likine, E. F., Sato, A. Y., McAndrews, K., Sanudo, C., Bruzzaniti, A., Riancho, J. A., Tonra, J. R., Bellido, T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: FASEB J. 2018 May;32(5):2878-2890

Editorial: Federation of American Society of Experimental Biology (FASEB)

 Fecha de publicación: 01/05/2018

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1096/fj.201700919RRR

ISSN: 0892-6638,1530-6860

Url de la publicación: https://dx.doi.org/10.1096/fj.201700919RRR

Autores/as

DELGADO CALLE, JESUS

HANCOCK, BENJAMIN

LIKINE, ELIVE F.

SATO, AMY Y.

MC ANDREWS, KEVIN

BRUZZANITI, ANGELA

TONRA, JAMES R.

BELLIDO, TERESITA