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Genetics of immunoglobulin-A vasculitis (Henoch-Schönlein purpura): An updated review

Abstract: Immunoglobulin-A vasculitis (IgAV) is classically a childhood small-sized blood vessel vasculitis with predominant involvement of the skin. Gastrointestinal and joint manifestations are common in patients diagnosed with this condition. Nephritis, which is more severe in adults, constitutes the most feared complication of this vasculitis. The molecular bases underlying the origin of IgAV have not been completely elucidated. Nevertheless, several pieces of evidence support the claim that genes play a crucial role in the pathogenesis of this disease. The human leukocyte antigen (HLA) region is, until now, the main genetic factor associated with IgAV pathogenesis. Besides a strong association with HLA class II alleles, specifically HLA-DRB1 alleles, HLA class I alleles also seem to influence on the predisposition of this disease. Other gene polymorphisms located outside the HLA region, including those coding cytokines, chemokines, adhesion molecules as well as those related to T-cells, aberrant glycosylation of IgA1, nitric oxide production, neoangiogenesis, renin-angiotensin system and lipid, Pyrin and homocysteine metabolism, may be implicated not only in the predisposition to IgAV but also in its severity. An update of the current knowledge of the genetic component associated with the pathogenesis of IgAV is detailed in this review.

 Fuente: Autoimmun Rev. 2018 Mar;17(3):301-315

Editorial: Elsevier

 Año de publicación: 2018

Nº de páginas: 15

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.autrev.2017.11.024

ISSN: 1568-9972,1873-0183

Url de la publicación: https://doi.org/10.1016/j.autrev.2017.11.024

Autores/as

LÓPEZ MEJÍAS, RAQUEL

CASTAÑEDA, SANTOS

FERNANDA GENRE

REMUZGO MARTÍNEZ, SARA

CARMONA, F. DAVID

RICARDO BLANCO ALONSO

MARTÍN, JAVIER