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Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Abstract: BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and >?2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.

 Fuente: BMC Cancer (2018) 18: 280

Editorial: BioMed Central

 Año de publicación: 2018

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1186/s12885-018-4182-3

ISSN: 1471-2407

Url de la publicación: https://doi.org/10.1186/s12885-018-4182-3

Autores/as

CAMILO PALAZUELOS CALDERON

JIMÉNEZ MOLEÓN, JOSÉ JUAN

ARAGONÉS, NURIA

ALTZIBAR, JONE M.

CASTAÑO VINYALS, GEMMA

MARTÍN SANCHEZ, VICENTE

GUEVARA, MARCELA

TARDÓN, ADONINA

PÉREZ GÓMEZ, BEATRIZ

AMIANO, PILAR

MORENO, VICTOR

MOLINA, ANTONIO J.

MORENO IRIBAS, CONCHI

KOGEVINAS, MANOLIS

POLLÁN, MARINA