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MicroRNA-30c-5p modulates neuropathic pain in rodents

Abstract: Neuropathic pain is a debilitating chronic syndrome that is often refractory to currently available analgesics. Aberrant expression of several microRNAs (miRNAs) in nociception-related neural structures is associated with neuropathic pain in rodent models. We have exploited the antiallodynic phenotype of mice lacking the bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI), a transforming growth factor-? (TGF-?) pseudoreceptor. We used these mice to identify new miRNAs that might be useful for diagnosing, treating, or predicting neuropathic pain. We show that, after sciatic nerve injury in rats, miR-30c-5p was up-regulated in the spinal cord, dorsal root ganglia, cerebrospinal fluid (CSF) and plasma and that the expression of miR-30c-5p positively correlated with the severity of allodynia. The administration of a miR-30c-5p inhibitor into the cisterna magna of the brain delayed neuropathic pain development and reversed fully established allodynia in rodents. The mechanism was mediated by TGF-? and involved the endogenous opioid system. In patients with neuropathic pain associated with leg ischemia, the expression of miR-30c-5p was increased in plasma and CSF compared to control patients without pain. Logistic regression analysis in our cohort of patients showed that the expression of miR-30c-5p in plasma and CSF, in combination with other clinical variables, might be useful to help to predict neuropathic pain occurrence in patients with chronic peripheral ischemia.

 Autoría: Tramullas M., Francés R., De La Fuente R., Velategui S., Carcelén M., García R., Llorca J., Hurlé M.A.,

 Fuente: Science Translational Medicine, 2018, 10(453), 6299

 Editorial: American Association for the Advancement of Science

 Fecha de publicación: 01/08/2018

 Nº de páginas: 14

 Tipo de publicación: Artículo de Revista

 DOI: 10.1126/scitranslmed.aao6299

 ISSN: 1946-6234,1946-6242

 Proyecto español: SAF2013-47434-R ; SAF2016-77732-R

 Url de la publicación: https://dx.doi.org/10.1126/scitranslmed.aao6299