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Association of circulating calprotectin with lipid profile in axial spondyloarthritis

Abstract: Calprotectin (CPT) is released during inflammation, also in the context of atherosclerosis. The link between CPT and the atherosclerotic process was evaluated in several diseases. However, studies in axial spondyloarthritis (axSpA), associated with a high incidence of subclinical atherosclerosis, are scarce. Therefore, we assessed the association of CPT with subclinical atherosclerosis and metabolic risk factors in axSpA. CPT serum levels were measured by enzyme-linked immunosorbent assay in 163 axSpA patients and 63 controls. Subclinical atherosclerosis was determined in patients by carotid ultrasonography (assessing the presence/absence of carotid plaques and carotid intima-media thickness [cIMT]). Data on inflammation, disease activity, lipid profile and treatment were collected to evaluate its relationship with CPT. axSpA patients evidenced lower CPT levels than controls. CPT showed no association with plaques or cIMT in axSpA. CPT and HDL-cholesterol negatively correlated, while a positive association of CPT with the atherogenic index was disclosed. Additionally, axSpA patients with C-reactive protein values at diagnosis higher than 3?mg/L displayed higher CPT levels. Our study shows no relationship between CPT and markers of subclinical atherosclerosis in axSpA. Nevertheless, it demonstrates an association of CPT with adverse lipid profiles and inflammatory biomarkers, which could further influence on the development of atherosclerosis.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Sci Rep. 2018 Sep 13;8(1):13728

Editorial: Nature Publishing Group

 Año de publicación: 2018

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41598-018-32199-3

ISSN: 2045-2322

Url de la publicación: https://dx.doi.org/10.1038/s41598-018-32199-3

Autores/as

FERNANDA GENRE

JAVIER RUEDA GOTOR

REMUZGO MARTÍNEZ, SARA

ALFONSO FERNANDO CORRALES MARTINEZ

VERONICA MIJARES DIAZ

EXPÓSITO, ROSA

MATA, CRISTINA

PORTILLA, VIRGINIA

RICARDO BLANCO ALONSO

GUALILLO, ORESTE

LÓPEZ MEJÍAS, RAQUEL