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Possible role of chondroitin sulphate and glucosamine for primary prevention of colorectal cancer. Results from the MCC-Spain study

Abstract: A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated. The reported frequency of chondroitin and/or glucosamine use was 2.03% in controls and 0.89% in cases. Users had a reduced risk of CRC (OR: 0.47; 95% CI: 0.28-0.79), but it was no longer significant when adjusted for NSAID (nonsteroidal anti-inflammatory drugs) use (OR: 0.82; 95% CI: 0.47-1.40). A meta-analysis with previous studies suggested a protective effect, overall and stratified by NSAID use (OR: 0.77; 95% CI: 0.62-0.97). We have not found strong evidence of an independent preventive effect of CG on CRC in our population because the observed effects of our study could be attributed to NSAIDs concurrent use. These results merit further research due to the safety profile of these drugs.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Sci Rep. 2018 Feb 1;8(1):2040

Editorial: Nature Publishing Group

 Año de publicación: 2018

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 1038/s41598-018-20349-6

ISSN: 2045-2322

Url de la publicación: https://dx.doi.org/1038/s41598-018-20349-6

Autores/as

IBÁÑEZ-SANZ, GEMMA

DÍEZ-VILLANUEVA, ANNA

VILORIO-MARQUÉS, LAURA

GRACIA, ESTHER

ARAGONÉS, NURIA

OLMEDO-REQUENA, ROCÍO

AMIANO, PILAR

NOS, PILAR

FERNÁNDEZ-TARDÓN, GUILLERMO

RADA, RICARDO

CHIRLAQUE, MARÍA DOLORES

GUINÓ, ELISABET

DÁVILA-BATISTA, VERÓNICA

CASTAÑO-VINYALS, GEMMA

PÉREZ-GÓMEZ, BEATRIZ

MIRÓN-POZO, BENITO

ETXEBERRIA, JAIONE