Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Abstract: Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P?C, p.Pro1054Arg) in ATM and rs2066827 (OR?=?1.06; P?=?2.3?×?10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk?=?2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk?=?5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1.

 Fuente: Nat Genet. 2018 Jul;50(7):928-936

Editorial: Nature Publishing Group

 Año de publicación: 2018

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41588-018-0142-8

ISSN: 1061-4036,1546-1718

Url de la publicación: https://doi.org/10.1038/s41588-018-0142-8

Autores/as

SCHUMACHER, FREDRICK R.

OLAMA, ALI AMIN AL

BERNDT, SONJA I.

BENLLOCH, SARA

AHMED, MAHBUBL

SAUNDERS, EDWARD J.

DADAEV, TOKHIR

LEONGAMORNLERT, DANIEL

ANOKIAN, EZEQUIEL

CIEZA-BORRELLA, CLARA

GOH, CHEE

BROOK, MARK N.

SHENG, XIN

FACHAL, LAURA

DENNIS, JOE

TYRER, JONATHAN

MUIR, KENNETH

LOPHATANANON, ARTITAYA

STEVENS, VICTORIA L.