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Pigmentation phototype and prostate and breast cancer in a select Spanish population - A Mendelian randomization analysis in the MCC-Spain study

Abstract: INTRODUCTION: Phototype has been associated with an increased risk of prostate cancer, and it is yet unknown if it is related to other hormone-dependent cancers, such as breast cancer or whether this association could be considered causal. METHODS: We examined the association between the phototype and breast and prostate cancers using a Mendelian randomization analysis. We studied 1,738 incident cases of breast cancer and another 817 cases of prostate cancer. To perform a Mendelian randomization analysis on the phototype-cancer relationship, a genetic pigmentation score was required that met the following criteria: (1) the genetic pigmentation score was associated with phototype in controls; (2) the genetic pigmentation score was not associated with confounders in the relationship between phototype and cancer, and (3) the genetic pigmentation score was associated with cancer only through its association with phototype. Once this genetic score is available, the association between genetic pigmentation score and cancer can be identified as the association between phototype and cancer. RESULTS: The association between the genetic pigmentation score and phototype in controls showed that a higher genetic pigmentation score was associated with fair skin, blond hair, blue eyes and the presence of freckles. Applying the Mendelian randomization analysis, we verified that there was no association between the genetic pigmentation score and cancers of the breast and prostate. CONCLUSIONS: Phototype is not associated with breast or prostate cancer.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: PLoS One. 2018 Aug 14;13(8):e0201750

Editorial: Public Library of Science

 Año de publicación: 2018

Nº de páginas: 15

Tipo de publicación: Artículo de Revista

 DOI: 10.1371/journal.pone.0201750

ISSN: 1932-6203

Url de la publicación: https://dx.doi.org/10.1371/journal.pone.0201750

Autores/as

CAMILO PALAZUELOS CALDERON

FERNÁNDEZ- NAVARRO, PABLO

CASTAÑO-VINYALS, GEMMA

URTIAGA, CARMEN

FERNÁNDEZ-VILLA, TANIA

ARDANAZ, EVA

RIVAS-DEL-FRESNO, MANUEL

MOLINA- BARCELÓ, ANA

JIMÉNEZ MOLEÓN, JOSÉ JUAN

GARCÍA MARTÍNEZ, LIDIA

AMIANO, PILAR

MARIA PAZ RODRIGUEZ CUNDIN

MORENO, VÍCTOR

PÉREZ GÓMEZ, BEATRIZ

ARAGONÉS, NURIA

KOGEVINAS, MANOLIS

POLLÁN, MARINA