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Comparison of the anti-inflammatory effect of aripiprazole and risperidone in 75 drug-naïve first episode psychosis individuals: a 3 months randomized study

Abstract: INTRODUCTION: Evidence about the anti-inflammatory properties of antipsychotics has grown. However, no previous studies have compared the immunomodulatory effect of risperidone and aripiprazole. OBJECTIVES: The main aim of the present work is to compare the anti-inflammatory effect of risperidone and aripiprazole on a large array of serum cytokines at 3?months following the onset of treatment. METHODS: This is a prospective, randomized, open-label study. Patients were randomly assigned to risperidone or aripiprazole. From this randomization, 75 patients and 75 healthy volunteers that matched with the selected patients were picked for entry in this study. Serum concentrations of 21 cytokines/chemokines were measured at baseline and 3?months following the initiation of antipsychotic medication. RESULTS: Those patients who were randomly assigned to risperidone had higher levels of IL-8 (p?=?0.000) and MIP-1? (p?=?0.007) than healthy volunteers at baseline, whereas no differences were found between patients initially assigned to aripiprazole and healthy volunteers. Three months following the onset of medication several cytokines decreased significantly: IL-8, MIP-1?, Fractalkine, TNF-?, IL-7, IL-13, IL-17?, IL-23, IL-21 (all ps?

 Fuente: Schizophrenia Research, 2018, 202, 226-233

 Editorial: Elsevier

 Año de publicación: 2018

 Nº de páginas: 8

 Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.schres.2018.06.039

 ISSN: 0920-9964,1573-2509

 Proyecto español: SAF2013-46292-R

 Url de la publicación: https://doi.org/10.1016/j.schres.2018.06.039

Autoría

JUNCAL RUIZ, MARÍA

RIESCO DÁVILA, LAURA

VICTOR ORTIZ GARCIA DE LA FOZ

OBDULIA MARTINEZ GARCIA

MARIA LUZ RAMIREZ BONILLA

JAVIER GONZALO OCEJO VIÑALS

LEZA, JUAN CARLOS

BENEDICTO CRESPO FACORRO