Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Gelsolin levels are decreased in ankylosing spondylitis patients undergoing anti-TNF-alpha therapy

Abstract: OBJECTIVES: To determine whether circulating gelsolin (GSN) levels in patients with ankylosing spondylitis (AS) undergoing TNF-a antagonist-infliximab-therapy are altered compared with controls and to establish whether disease activity, systemic inflammation and metabolic syndrome are potential determinants of circulating GSN levels in these patients. METHODS: We assessed GSN serum concentrations in a series of 30 non-diabetic AS patients without cardiovascular (CV) disease undergoing TNF-a antagonist-infliximab therapy and 48 matched controls. GSN levels were measured immediately before and after an infliximab infusion. Correlations of GSN serum levels with disease activity, systemic inflammation and metabolic syndrome were assessed. Potential changes in GSN concentration following an infusion of anti-TNF-a monoclonal antibody-infliximab were also analysed. RESULTS: Although at the time of the study AS patients undergoing anti-TNF-a therapy had adequate control of the disease (mean BASDAI 2.94), they showed lower GSN serum levels than healthy controls (mean±SD: 38660.42±23624.6 ng/ml versus 68975.43±31246.79 ng/ml; p<0.0001). When AS patients were stratified according to sex, we observed that GSN levels were significantly lower in men than in women (p=0.032). However, no differences in GSN levels according to the specific clinical features of the disease were seen. No association was found between GSN concentration and adipokines or biomarkers of endothelial cell activation. However, correlation between basal GSN levels and insulin resistance was observed. A single infliximab infusion did not lead to significant changes in GSN levels. CONCLUSIONS: GSN concentration is reduced in AS patients undergoing periodical anti-TNF-a therapy and low disease activity. Potential association with some metabolic syndrome features seems to exist.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clin Exp Rheumatol. 2014 Mar-Apr;32(2):218-24

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2014

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Proyecto español: PI06/0024, PS09/00748,PI12/00060

Autores/as

GENRE, FERNANDA

LÓPEZ MEJÍAS, R

MIRANDA FILLOY, JA

UBILLA GARCÍA, BEGOÑA

CARNERO LÓPEZ, B

RICARDO BLANCO ALONSO

OCHOA, R

RUEDA GOTOR, J

GONZÁLEZ JUANATEY, C