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Predictors of positive (18) F-FDG PET/CT-scan for large vessel vasculitis in patients with persistent polymyalgia rheumatica

Abstract: Abstract: Objective: Polymyalgiarheumatica(PMR)isoftenthepresenting manifestationofgiantcellarteritis(GCA). Fluorine-18-fluorodeoxyglucosepositronemissiontomography/computedtomography(PET/CT)scanoften disclosesthepresenceoflargevesselvasculitis(LVV)inPMRpatients.Weaimedtoidentifypredictivefactorsof a positivePET/CTscanforLVVinpatientsclassifiedashavingisolatedPMRaccordingtowell-establishedcriteria. Methods: A setofconsecutivepatientswithPMRfromasinglehospitalwereassessed.Allofthemunderwent PET/CT scanbetweenJanuary2010andFebruary2018based onclinicalconsiderations.PatientswithPMR associatedtootherdiseases,includingthosewithcranialfeaturesofGCA,wereexcluded.Theremaining patients werecategorizedinclassicPMR(iffulfilledthe2012EULAR/ACRclassification criteriaatdisease diagnosis; n ¼ 84) oratypicalPMR(whodidnotfulfill thesecriteria; n ¼ 16).Onlyinformationonpatients withclassicPMRwasassessed. Results: Themeanageofthe84patients(51women)withclassicPMRwas71.4 7 9.2 years.APET/CTscanwas positivein51(60.7%).PersistenceofclassicPMRsymptomswasthemostcommonreasontoperformaPET/CT scan.Nevertheless,patientswithpositivePET/CTscanoftenhadunusualsymptoms.Thebestsetofpredictorsof a positivePET/CTscanwerebilateraldiffuselowerlimbpain(OR ¼ 8.8,95%CI:1.7?46.3; p ¼ 0.01),pelvicgirdle pain(OR ¼ 4.9,95%CI:1.50?16.53; p ¼ 0.01)andinflammatorylowbackpain(OR ¼ 4.7,95%CI:1.03?21.5; p ¼ 0.04).

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Seminars in Arthritis and Rheumatism, Volume 48, Issue 4, February 2019, Pages 720-727

Editorial: Elsevier

 Fecha de publicación: 01/02/2019

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2018.05.007

ISSN: 0049-0172,1532-866X

Url de la publicación: https://doi.org/10.1016/j.semarthrit.2018.05.007

Autores/as

PRIETO PEÑA, DIANA

Mª ISABEL MARTINEZ RODRIGUEZ

JAVIER LORICERA GARCIA

BANZO MARRACO, JOSE IGNACIO

CALDERÓN GOERCKE, MÓNICA

CALVO RÍO, VANESA

ALFONSO FERNANDO CORRALES MARTINEZ

CASTAÑEDA, SANTOS

RICARDO BLANCO ALONSO