Estamos realizando la búsqueda. Por favor, espere...
Abstract: Background: The association between chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis, and insulin resistance (IR) has been well established. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine glandbearing areas of the body.
Objective: We aimed to determine the prevalence of IR in patients with HS.
Methods: This cross-sectional, case-control study enrolled 137 subjects, 76 patients with HS and 61 age- and gender-matched controls. Demographic data, clinical examination of HS patients, anthropometric measures, cardiovascular risk factors and laboratory studies were recorded. The homeostasis model assessment of IR (HOMA-IR) was calculated in all participants by measuring fasting plasma glucose and insulin levels.
Results: The median (IQR) HOMA-IR value in HS patients was significantly higher [2.0 (1.0-3.6)] than in controls [1.5(0.9-2.3)] (p=0.01). The prevalence of IR was significantly higher in cases (43.4%) compared with controls (16.4%) (p=0.001). In the linear regression multivariable analysis after adjusting for age, sex and body mass index (BMI), HS remained as a significant factor for a higher HOMA-IR [2.51(0.18) vs 1.92(0.21); p=0.04]. The HOMA-IR value and the prevalence of IR did not differ significantly among HS patients grouped by severity of the disease.
Conclusion: Our results show an increased frequency of IR in HS. Thus, we suggest HS patients to be evaluated for IR and managed accordingly.
Fuente: J Eur Acad Dermatol Venereol. 2018 May;32(5):820-824
Fecha de publicación: 01/05/2018
Nº de páginas: 19
Tipo de publicación: Artículo de Revista
Consultar en UCrea Leer publicación
VILANOVA URDANIZ, IOSUNE
JOSE LUIS HERNANDEZ HERNANDEZ
MATA ARNAIZ, MARÍA CRISTINA
MARIA TERESA GARCIA UNZUETA
PORTILLA GONZÁLEZ, VIRGINIA
FUENTEVILLA RODRÍGUEZ, PATRICIA
ALFONSO FERNANDO CORRALES MARTINEZ
MARIA CARMEN GONZALEZ VELA
MIGUEL ANGEL GONZALEZ-GAY MANTECON
RICARDO BLANCO ALONSO
MARCOS ANTONIO GONZALEZ LOPEZ