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 Detalle_Publicacion

Whole-exome sequencing in splenic marginal zone lymphoma reveals mutations in genes involved in marginal zone differentiation

Abstract: rginal zone lymphoma (SMZL) is a B-cell neoplasm whose molecular pathogenesis remains fundamentally unexplained, requiring more precise diagnostic markers. Previous molecular studies have revealed 7q loss and mutations of nuclear factor ?B (NF-?B), B-cell receptor (BCR) and Notch signalling genes. We performed whole-exome sequencing in a series of SMZL cases. Results confirmed that SMZL is an entity distinct from other low-grade B-cell lymphomas, and identified mutations in multiple genes involved in marginal zone development, and others involved in NF-?B, BCR, chromatin remodelling and the cytoskeleton

 Fuente: Leukemia. 2014 Jun;28(6):1334-40

Editorial: Nature Publishing Group

 Fecha de publicación: 01/06/2014

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/leu.2013.365

ISSN: 0887-6924,1476-5551

Proyecto español: RTICC RD06/ 0020/0107, RD12/0036/0060, PI 12/1682 ; SAF2008–03871

Autores/as

GONZÁLEZ FERNÁNDEZ, NEREA

ALMARÁZ PRO, CARMEN

DERDAK, SOPHIA

BELTRÁN AGULLÓ, SERGI

MOLLEJO, MANUELA

CAMPOS MARTÍN, YOLANDA

ÁGUEDA, LÍDIA

RINALDI, ANDREA

KWEE, IVO

GUT, M.

BLANC, JULIE

OSCIER, DAVID

STREFFORD, JONATHAN C.

MARTÍNEZ LÓPEZ, JOAQUÍN

SALAR, ANTONIO

SOLÉ, FRANCESC

RODRÍGUEZ PERALTO, JOSE LUIS

DIEZ TASCÓN, CRISTINA

GARCÍA GARCÍA, JUAN FERNANDO

FRAGA RODRÍGUEZ, MÁXIMO

SEBASTIAN, E.

ÁLVES FERREIRA, FRANCISCO JAVIER

MENÁRGUEZ PALANCA, JAVIER

GONZÁLEZ-CARRERÓ, JOAQUÍN

CASADO, L. FELIPE

MÓNICA, BAYÈS

BERTONI, FRANCESCO

GUT, IVO

MIGUEL ANGEL PIRIS PINILLA