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Multi-walled carbon nanotubes complement the anti-tumoral effect of 5-Fluorouracil

Abstract: Multiple-drug resistance in human cancer is a major problem. To circumvent this issue, clinicians combine several drugs. However, this strategy could backfire resulting in more toxic or ineffective treatments. Carbon nanotubes (CNTs), and particularly multi-walled nanotubes (MWCNTs), display intrinsic properties against cancer interfering with microtubule dynamics and triggering anti-proliferative, anti-migratory and cytotoxic effects in vitro that result in tumor growth inhibition in vivo. Remarkably, these effects are maintained in tumors resistant to traditional microtubule-binding chemotherapies such as Taxol®. In the view of these properties, we investigate the use of MWCNTs in the development of active-by-design nanocarriers, attempting to enhance the effect of broadly-used chemotherapies. We compare the cytotoxic and the anti-tumoral effect of 5-Fluorouracil (5-FU) -an antimetabolite treatment of various forms of cancer- with that of the drug physisorbed onto MWCNTs. Our results demonstrate how the total effect of the drug 5-FU is remarkably improved (50% more effective) when delivered intratumorally coupled to MWCNTs both in vitro and in vivo in solid tumoral models. Our results demonstrate how using MWCNTs as anti-cancer drug delivery platforms is a promising approach to boost the efficacy of traditional chemotherapies, while considerably reducing the chances of resistance in cancer cells.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: González-Lavado E., Valdivia L., García-Castaño A., González F., Pesquera C., Valiente R., Fanarraga M.,

 Fuente: Oncotarget, 2019, 10(21), 2022-2029

Editorial: Impact Journals

 Fecha de publicación: 12/03/2019

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.18632/oncotarget.26770

ISSN: 1949-2553

Proyecto español: MAT2015-69508-P ; MAT2016-81955- -REDT

Autores/as

ELOISA GONZALEZ LAVADO

LOURDES MARIA VALDIVIA FERNANDEZ

MARIA DE LA ALMUDENA GARCIA CASTAÑO

FERNANDO GONZALEZ MARTINEZ

M. CARMEN PESQUERA GONZALEZ