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 Detalle_Publicacion

Hyperlipoproteinaemia(a) in patients with spondyloarthritis: results of the Cardiovascular in Rheumatology (CARMA) project

Abstract: OBJECTIVES: Cardiovascular (CV) disease is one of the main causes of morbi-mortality in spondyloarthritis (SpA), partially explained by traditional CV risk factors. Information on lipoprotein(a) [Lp(a)], a non-conventional risk factor, in SpA is scarce. In this study we assessed the prevalence of hyperlipoproteinaemia(a) in SpA patients and analysed the possible related factors. METHODS: A baseline analysis was made of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) patients and controls included in the CARMA project (CARdiovascular in RheuMAtology), a 10-year prospective study evaluating the risk of CV events in chronic inflammatory rheumatic diseases. A multivariate logistic regression model was performed using hyperlipoproteinaemia(a) (Lp(a) >50 mg/dl) as a dependent variable and adjusting for confounding factors. RESULTS: 19.2% (95% CI: 16.80-22.05) of the SpA patients [20.7% (95% CI: 16.91-24.82) of those with AS and 17.7% (95% CI: 14.15-21.75) of those with PsA] and 16.7% (95% CI: 13.23-20.86) of the controls had hyperlipoproteinaemia(a) (p=0.326). Adjusting for age and sex, SpA patients were more likely to have hyperlipoproteinaemia(a) than controls (OR: 1.43, 95%CI: 1.00-2.04; p=0.05), especially those with AS (OR: 1.81, 95%CI: 1.18-2.77; p=0.007). In the adjusted model, apolipoprotein B in all patients, non-steroidal anti-inflammatory drugs in AS, and female sex in PsA, were associated with hyperlipoproteinaemia(a). No disease-specific factors associated with hyperlipoproteinaemia(a) were identified. CONCLUSIONS: SpA patients show a moderately increased risk of hyperlipoproteinaemia(a) compared to controls, especially those with AS. Lp(a) determination may be of interest to improve the CV risk assessment in SpA patients.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clin Exp Rheumatol. 2019 Sep-Oct;37(5):774-782

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2019

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

GARCÍA-GÓMEZ, C.

MARTÍN-MARTÍNEZ, M.A.

FERNÁNDEZ-CARBALLIDO, C.

CASTAÑEDA, S.

GONZÁLEZ-JUANATEY, C.

SANCHEZ-ALONSO, F.

GONZÁLEZ-FERNÁNDEZ, M.J.

SANMARTÍ, R.

GARCÍA-VADILLO, J.A.

FERNÁNDEZ-GUTIÉRREZ, B.

GARCÍA-ARIAS, M.

MANERO, F.J.

SENABRE, J.M.

RUEDA-CID, A.

ROS-EXPÓSITO, S.

PINA-SALVADOR, J.M.

ERRA-DURÁN, A.

MÖLLER-PARERA, I.

CARMA PROJECT COLLABORATIVE GROUP