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Adherence to the 2018 WCRF/AICR cancer prevention guidelines and chronic lymphocytic leukemia in the MCC-Spain study

Abstract: Introduction: Preventable risk factors for chronic lymphocytic leukemia (CLL) remain largely unknown. The aim of this study was to evaluate the association between adherence to nutrition-based guidelines for cancer prevention and CLL, in the MCC-Spain case-control study. Methods: A total of 318 CLL cases and 1293 population-based controls were included in the present study. The World Cancer Research Fund/American Institute for Cancer Research (WCRC/AICR) score based on the 2018 recommendations for cancer prevention (on body fatness, physical activity, and diet) was constructed. We used logistic regression analysis adjusting for potential confounders. Results: Individuals in the highest tertile of the WCRF/AICR score had an odds ratio for CLL of 1.25 (95 % CI 0.91; 1.73) compared with individuals with low adherence (p-trend = 0.172). Each point increment in the score was associated with an OR for CLL of 1.06 (95 % CI 0.91; 1.23). Analyses by severity of disease did not show significant heterogeneity of effects. Conclusion: Overall, our results do not support an association between the WCRF/AICR score and CLL, yet we might have been limited by statistical power and study design to detect modest associations. Further research, ideally with a prospective design, long follow-up, and including additional lymphoma subtypes, is warranted to confirm the impact of composite healthy lifestyle behaviors on lymphoma risk.

 Autoría: Solans M., Romaguera D., Gracia-Lavedan E., Molinuevo A., Benavente Y., Saez M., Marcos-Gragera R., Costas L., Robles C., Alonso E., de la Banda E., Gonzalez-Barca E., Llorca J., Rodriguez-Suarez M.M., Lozano-Lorca M., Aymerich M., Campo E., Gimeno-Vázquez E., Castaño-Vinyals G., Aragonés N., Pollán M., Kogevinas M., de Sanjose S., Amiano P., Casabonne D.,

 Fuente: Cancer Epidemiology. Volume 64, February 2020: 101629

Editorial: Elsevier

 Año de publicación: 2020

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.canep.2019.101629

ISSN: 1877-7821,1877-783X

Url de la publicación: https://doi.org/10.1016/j.canep.2019.101629

Autores/as

SOLANS, MARTA

ROMAGUERA, DORA

GRACIA-LAVEDAN, ESTHER

MOLINUEVO, AMAIA

BENAVENTE, YOLANDA

SAEZ, MARC

MARCOS-GRAGERA, RAFAEL

COSTAS, LAURA

ROBLES, CLAUDIA

ALONSO, ESTHER

BANDA, ESMERALDA DE LA

GONZALEZ-BARCA, EVA

RODRIGUEZ-SUAREZ, MARTA MARIA

LOZANO-LORCA, MACARENA

AYMERICH, MARTA

CAMPO, ELIAS

GIMENO-VÁZQUEZ, EVA

CASTAÑO-VINYALS, GEMMA

ARAGONÉS, NURIA