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Alkylphenolic compounds and risk of breast and prostate cancer in the MCC-Spain study

Abstract: Background: Alkylphenolic compounds are chemicals with endocrine disrupting properties that have been widely used in industry with important changes in their usage over time. Few epidemiologic studies have evaluated the effect of alkylphenolic compounds on human health. Objectives: We investigated whether occupational exposure to alkylphenolic compounds is associated with breast and prostate cancer. Methods: We carried out a population-based case-control study including 1513 incident cases of breast cancer, 1095 of prostate cancer, and 3055 controls, frequency matched by sex, age and region. Occupational exposure to alkylphenolic compounds was estimated using a recently developed job-exposure matrix, which considered different scenarios of exposure and different subtypes of alkylphenolic compounds. Results: History of occupational exposure to alkylphenolic compounds was modestly associated with breast cancer (OR = 1.23; 95% CI = 1.01-1.48). Within the different scenarios, the occupational use of domestic tensioactives was positively associated with breast cancer (OR = 1.28; 95% CI = 1.02-1.60), while occupational exposure in other scenarios showed mostly a suggestion of a similar positive associations. Exposure to nonylphenol ethoxylates was positively associated with breast cancer (OR = 1.21; 95% CI = 1.00-1.47), while exposure to other compounds was uncommon. In general, we did not observe associations between alkylphenolic compounds and prostate cancer, except for a positive association among men occupationally exposed to cosmetic, hair and personal hygiene products. Conclusions: Our findings suggest a modest association between breast cancer risk and occupational exposure to alkylphenolic compounds, and no associations between these compounds and prostate cancer risk. These findings warrant further corroboration in other studies.

 Fuente: Environ Int. 2019 Jan;122:389-399

Editorial: Elsevier

 Año de publicación: 2019

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.envint.2018.12.007

ISSN: 0160-4120,1873-6750

Url de la publicación: https://doi.org/10.1016/j.envint.2018.12.007

Autores/as

PEREMIQUEL-TRILLAS, PAULA

BENAVENTE, YOLANDA

MARTÍN-BUSTAMANTE, MAYTE

CASABONNE, DELPHINE

PÉREZ-GÓMEZ, BEATRIZ

OLIETE-CANELA, ANNA

DIÉGUEZ-RODRÍGUEZ, MARTA

TUSQUETS, IGNASI

AMIANO, PILAR

MENGUAL, LOURDES

ARDANAZ, EVA

CAPELO, ROCÍO

MOLINA DE LA TORRE, ANTONIO J.

SALAS TREJO, DOLORES

FERNÁNDEZ-TARDÓN, GUILLERMO

LOPE, VIRGINIA

JIMENEZ-MOLEON, JOSÉ J.

MARCOS-GRAGERA, RAFAEL