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Melatonin Modulation of Radiation and Chemotherapeutics-induced Changes on Differentiation of Breast Fibroblasts


Abstract: Melatonin exerts oncostatic actions and sensitizes tumor cells to chemotherapeutics or radiation. In our study, we investigated the e ects of docetaxel, vinorelbine, and radiation on human breast fibroblasts and its modulation by melatonin. Docetaxel or vinorelbine inhibits proliferation and stimulates the di erentiation of breast preadipocytes, by increasing C/EBP and PPAR expression and by downregulating tumor necrosis factor (TNF ), interleukin 6 (IL-6), and IL-11 expression. Radiation inhibits both proliferation and di erentiation through the downregulation of C/EBP and PPAR and by stimulating TNF expression. In addition, docetaxel and radiation decrease aromatase activity and expression by decreasing aromatase promoter II and cyclooxygenases 1 and 2 (COX-1 and COX-2) expression. Melatonin potentiates the stimulatory e ect of docetaxel and vinorelbine on di erentiation and their inhibitory e ects on aromatase activity and expression, by increasing the stimulatory e ect on C/EBP and PPAR expression and the downregulation of antiadipogenic cytokines and COX expression. Melatonin also counteracts the inhibitory e ect of radiation on di erentiation of preadipocytes, by increasing C/EBP and PPAR expression and by decreasing TNF expression. Melatonin also potentiates the inhibitory e ect exerted by radiation on aromatase activity and expression by increasing the downregulation of promoter II, and COX-1 and COX-2 expression. Our findings suggest that melatonin modulates regulatory e ects induced by chemotherapeutic drugs or radiation on preadipocytes, which makes it a promising adjuvant for chemotherapy and radiotherapy sensibilization.

 Fuente: Int J Mol Sci. 2019 Aug; 20(16): 3935

Editorial: MDPI

 Año de publicación: 2019

Nº de páginas: 18

Tipo de publicación: Artículo de Revista

DOI: 10.3390/ijms20163935

ISSN: 1661-6596,1422-0067

Proyecto español: SAF2016-77103-P

Url de la publicación: https://www.doi.org/10.3390/ijms20163935

Autores/as

GONZÁLEZ-GONZÁLEZ, ALICIA

GARCÍA NIETO, ENRIQUE

CRISTINA SANCHEZ FERNANDEZ

MENÉNDEZ-MENÉNDEZ, JAVIER