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Abstract: Neuromyopathy is a rare side effect of chronic colchicine therapy, especially without renal impairment. Drugs interacting with colchicine metabolism through CYP3A4 can accelerate accumulation and toxicity. We describe a case of an interaction between atorvastatin, clarithromycin and colchicine resulting in acute neuromyopathy. Learning points: Colchicine has a narrow therapeutic window, and therefore, often produces side effects.Special caution should be adopted if patients with renal disease and concomitant medications are given colchicine.Before prescribing colchicine, the clinical history, including previous medications and conditions, should be carefully considered.
Fuente: European Journal of Case Reports in Internal Medicine, 2019, 6(3), 001066
Editorial: SMC Media
Año de publicación: 2019
Nº de páginas: 3
Tipo de publicación: Artículo de Revista
DOI: 10.12890/2019_001066
ISSN: 2284-2594
Url de la publicación: https://www.doi.org/10.12890/2019_001066
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JOSE MANUEL OLMOS MARTINEZ
MOLINA, HELENA
SALAS, CRISTINA
OLMOS, JOSÉ M.
JOSE LUIS HERNANDEZ HERNANDEZ
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