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Fatty acid intake and breast cancer in the spanish multicase-control study on cancer (MCC-Spain)

Abstract: Purpose: To evaluate the association between dietary fat and fat subtype and breast cancer development. Methods: We conducted a case-control study with 1181 cases of incident breast cancer, diagnosed between 2007 and 2012, and 1682 population controls frequency matched (by age, sex, and region) from the Spanish multicenter case-control study MCC-Spain. Results: We found a significant protective effect in premenopausal women of total fat intake [OR 0.51 95% CI (0.31-0.86) highest versus lowest tertile], but no effect was observed in menopausal women [OR 1.15 95% CI (0.83-1.60)]. Analyzing by type of fat, this protective effect persisted only for the monounsaturated fatty acids [OR 0.51 95% CI (0.32-0.82)]. In contrast, other fatty acids did not have a significant effect. In addition, a protection against risk of breast cancer was found when polyunsaturated fats were "substituted" by monounsaturated, maintaining the same total fat intake [OR 0.68 95% CI (0.47-0.99)]. Finally, analyzing by breast cancer subtype, we found no effect, except in premenopausal women where intake of moderate [OR 0.52 95% CI (0.33-0.82)] and high monounsaturated fatty acids [OR 0.47 95% CI (0.27-0.82)] maintains a protective effect against ER/PR + tumors. In contrast, in menopausal women, a high intake of monounsaturated fatty acids was associated with higher risk of HER2 + tumors [OR 2.00 95% CI (0.97-4.13)]. Conclusion: Our study shows a differential effect of monounsaturated fatty acids according to menopausal status and breast cancer subtype.

 Autoría: Dierssen-Sotos T., Gómez-Acebo I., Palazuelos C., Gracia-Lavedan E., Pérez-Gómez B., Oribe M., Martín V., Guevara M., Rodríguez-Cundín P., Fernández-Tardón G., Marcos-Gragera R., Molina-Barceló A., Díaz-Santos M., Castaño-Vinyals G., Aragonés N., López-Gonzalez A., Amiano P., Castilla J., Alonso-Molero J., Kogevinas M., Pollán M., Llorca J.,

 Fuente: Eur J Nutr . 2020 Apr;59(3):1171-1179

Editorial: Steinkopff

 Año de publicación: 2020

Nº de páginas: 9

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s00394-019-01977-8

ISSN: 1436-6215,1436-6207

Url de la publicación: https://doi.org/10.1007/s00394-019-01977-8

Autores/as

CAMILO PALAZUELOS CALDERON

GRACIA LAVEDAN, ESTHER

PÉREZ GÓMEZ, BEATRIZ

ORIBE, MADALEN

MARTÍN, VICENTE

GUEVARA, MARCELA

RODRÍGUEZ CUNDÍN, PAZ

FERNÁNDEZ TARDÓN, GUILLERMO

MARCOS GRAGERA, RAFAEL

MOLINA BARCELÓ, ANA

DÍAZ SANTOS, MARIAN

CASTAÑO VINYALS, GEMMA

ARAGONÉS, NURIA

LÓPEZ GONZALEZ, ANA

AMIANO, PILAR

CASTILLA, JESÚS

KOGEVINAS, MANOLIS