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Abstract: Objective: To study the outcomes of patients with acute heart failure (AHF) presenting renal dysfunction (RD) or
hyperkalaemia (Hk) alone or in combination.
Method: We analysed the data of the EAHFE registry, a multicentre, non interventionist cohort with prospective
follow-up of patients with AHF. Four groups were defined based on the presence or not of RD or Hk alone or in
combination. The primary endpoint was 30-day all-cause mortality.
Results: A total of 11,935 of the 13,791 patients included in the EAHFE registry were analysed. Of these, 5088
(42.6%) did not have RD or Hk (NoRD-NoHk), 150 (1.3%) had no RD but had Hk (NoRD-Hk), 6012 (50.4%) had
RD but not Hk (RD-NoHk) and 685 (5.7%) had both RD and Hk (RD-Hk). Thirty-day all-cause mortality was
greatest in the RD-Hk group with an adjusted Hazard Ratio (HR) of 2.44 (confidence interval 95% [CI95%]
1.67?3.55; p < 0.001) and in the RD-NoHk group with an adjusted HR of 1.34 (CI95% 1.04?1.71; p=0.022).
There were no significant differences in in-hospital mortality and reconsultation at 30 days for HF. For the
combined endpoint of 30-day all-cause mortality the adjusted HR was 1.33 (CI95% 1.04?1.70); (p=0.021) for
the RD-Hk group.
Conclusions: The association of 30-day all-cause mortality with the presence of RD and Hk in patients presenting
AHF at admission is greater than in those without this combination.
Fuente: European journal of internal medicine 2019 67, 89-96
Año de publicación: 2019
Nº de páginas: 8
Tipo de publicación: Artículo de Revista
Url de la publicación: https://doi.org/10.1016/j.ejim.2019.07.010
MARTÍN-SÁNCHEZ, FRANCISCO JAVIER
LUCAS-IMBERNÓN, FRANCISCO JAVIER
HECTOR ALONSO VALLE
SANTOS-MATALLANA, MARIA CARMEN
DOCAVO BARRENECHEA-MOXÓ, MARÍA LUISA