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 Detalle_Publicacion

Acute heart failure and adverse events associated with the presence of renal dysfunction and hyperkalaemia. EAHFE-renal dysfunction and hyperkalaemia

Abstract: Objective: To study the outcomes of patients with acute heart failure (AHF) presenting renal dysfunction (RD) or hyperkalaemia (Hk) alone or in combination. Method: We analysed the data of the EAHFE registry, a multicentre, non interventionist cohort with prospective follow-up of patients with AHF. Four groups were defined based on the presence or not of RD or Hk alone or in combination. The primary endpoint was 30-day all-cause mortality. Results: A total of 11,935 of the 13,791 patients included in the EAHFE registry were analysed. Of these, 5088 (42.6%) did not have RD or Hk (NoRD-NoHk), 150 (1.3%) had no RD but had Hk (NoRD-Hk), 6012 (50.4%) had RD but not Hk (RD-NoHk) and 685 (5.7%) had both RD and Hk (RD-Hk). Thirty-day all-cause mortality was greatest in the RD-Hk group with an adjusted Hazard Ratio (HR) of 2.44 (confidence interval 95% [CI95%] 1.67?3.55; p < 0.001) and in the RD-NoHk group with an adjusted HR of 1.34 (CI95% 1.04?1.71; p=0.022). There were no significant differences in in-hospital mortality and reconsultation at 30 days for HF. For the combined endpoint of 30-day all-cause mortality the adjusted HR was 1.33 (CI95% 1.04?1.70); (p=0.021) for the RD-Hk group. Conclusions: The association of 30-day all-cause mortality with the presence of RD and Hk in patients presenting AHF at admission is greater than in those without this combination.

 Fuente: European journal of internal medicine 2019 67, 89-96

Editorial: Elsevier

 Año de publicación: 2019

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.ejim.2019.07.010

ISSN: 0953-6205,1879-0828

Url de la publicación: https://doi.org/10.1016/j.ejim.2019.07.010

Autores/as

JACOB, JAVIER

LLAUGER, LLUIS

HERRERO-PUENTE, PABLO

MARTÍN-SÁNCHEZ, FRANCISCO JAVIER

LLORENS, PERE

ROSET, ALEX

GIL, VÍCTOR

FUENTES, MARTA

LUCAS-IMBERNÓN, FRANCISCO JAVIER

MIRÓ, ÓSCAR

ICASEMES-RESEARCH GROUP

GIL, CRISTINA

PÉREZ-LLANTADA, ENRIQUE

LLOPIS-GARCÍA, GUILLERMO

SANTOS-MATALLANA, MARIA CARMEN

DOCAVO BARRENECHEA-MOXÓ, MARÍA LUISA

SALGADO-PÉREZ, LUCÍA

ESCODA, ROSA

XIPELL, CAROLINA