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Late Plasma Cell Depletion After Thymoglobulin Induction in Kidney Transplant Recipients

Abstract: Objectives: Induction therapy with rabbit antithymocyte globulin is frequently used in kidney transplant recipients and contributes to regulating the humoral alloantibody response. However, the effect of rabbit antithymocyte globulin on B-cell subpopulations, including plasma cells, has not been previously studied in humans in vivo. Materials and methods: We prospectively studied a cohort of 39 adult kidney transplant recipients. Twenty patients received rabbit antithymocyte globulin as induction therapy. Peripheral blood samples were obtained pretransplant and at 6 and 12 months posttransplant. T and B cells were acquired by flow cytometry. Results: Total lymphocytes and CD3 and CD4 cells significantly decreased at 6 and 12 months only in patients who received rabbit antithymocyte globulin. In contrast, the CD19 population did not change after rabbit antithymocyte globulin induction. One-year circulating plasma cells remained significantly lower than pretransplant levels in patients who received rabbit antithymocyte globulin. We observed sig-nificant differences in plasma cell numbers at 12 months after transplant between patients who received rabbit antithymocyte globulin and those patients who did not receive it (median of 5 and interquartile range of 3-17 vs median of 25 and interquartile range of 12-35; P = .001). Conclusions: Rabbit antithymocyte globulin induction leads to a late reduction in the number of circulating plasma cells at 1 year after kidney transplant. This effect can contribute to down-regulation of the humoral alloantibody response.

 Fuente: Exp Clin Transplant . 2019 Dec;17(6):732-738

Editorial: Baskent University

 Año de publicación: 2019

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

 DOI: 10.6002/ect.2018.026

ISSN: 1304-0855,2146-8427

Url de la publicación: http://www.ectrx.org/forms/ectrxcontentshow.php?year=2019&volume=17&issue=6&supplement=0&makale_no=0&spage_number=732&content_type=FULL%20TEXT