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 Detalle_Publicacion

Effect of Continuous Positive Airway Pressure on Inflammatory, Antioxidant, and Depression Biomarkers in Women With Obstructive Sleep Apnea: A Randomized Controlled Trial

Abstract: Study objectives: The effect of continuous positive airway pressure (CPAP) on mediators of cardiovascular disease and depression in women with obstructive sleep apnea (OSA) is unknown. We aimed to assess the effect of CPAP therapy on a variety of biomarkers of inflammation, antioxidant activity, and depression in women with OSA. Methods: We conducted a multicenter, randomized controlled trial in 247 women diagnosed with moderate-to-severe OSA (apnea-hypopnea index [AHI] ? 15). Women were randomized to CPAP (n = 120) or conservative treatment (n = 127) for 12 weeks. Changes in tumor necrosis factor ? (TNF?), interleukin 6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), catalase (CAT), superoxide dismutase (SOD), and brain-derived neurotrophic factor (BDNF) were assessed. Additional analyses were conducted in subgroups of clinical interest. Results: Women had a median (25th-75th percentiles) age of 58 (51-65) years, body mass index 33.5 (29.0-38.3) kg/m2, and AHI 33.3 (22.8-49.3). No differences were found between groups in the baseline levels of the biomarkers. After 12 weeks of follow-up, there were no changes between groups in any of the biomarkers assessed. These results did not change when the analyses were restricted to sleepy women or to those with severe OSA. In women with CPAP use at least 5 hours per night, only TNF? levels decreased compared to the control group (-0.29 ± 1.1 vs -0.06 ± 0.53, intergroup difference -0.23 [95% CI = -0.03 to -0.50]; p = 0.043). Conclusions: Twelve weeks of CPAP therapy does not improve biomarkers of inflammation, antioxidant activity, or depression compared to conservative treatment in women with moderate-to-severe OSA.

 Fuente: Sleep . 2019 Oct 9;42(10):zsz145

Editorial: Oxford University Press

 Fecha de publicación: 01/10/2019

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.1093/sleep/zsz145

ISSN: 0161-8105,1550-9109

Url de la publicación: https://www.doi.org/10.1093/sleep/zsz145

Autores/as

CAMPOS-RODRIGUEZ, FRANCISCO

ASENSIO-CRUZ, MARIA ISABEL

CORDERO-GUEVARA, JOSE

JURADO-GAMEZ, BERNABE

CARMONA-BERNAL, CARMEN

TRONCOSO, MARIA F.

SANCHEZ-LOPEZ, VERONICA

ARELLANO-ORDEN, ELENA

GARCIA-SANCHEZ, MARIA ISABEL

MARTINEZ-GARCIA, MIGUEL ANGEL

SPANISH SLEEP NETWORK