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The poor prognosis of low hypodiploidy in adults with B-cell precursor acute lymphoblastic leukaemia is restricted to older adults and elderly patients

Abstract: The prognostic significance of low-hypodiploidy has not been extensively evaluated in minimal residual disease (MRD)-oriented protocols for adult acute lymphoblastic leukaemia (ALL). We analysed the outcome of hypodiploid adult ALL patients treated within Programa Español de Tratamientos en Hematología (PETHEMA) protocols. The 5-year cumulative incidence of relapse (CIR) of low-hypodiploid B-cell precursor (BCP)-ALL was significantly higher than that of high-hypodiploids (52% vs. 12%, P = 0.013). Low-hypodiploid BCP-ALL patients aged ?35 years showed superior survival (71% vs. 21%, P = 0.026) and lower 5-year CIR (17% vs. 66%, P = 0.090) than low-hypodiploids aged >35 years. Older adults and elderly low-hypodiploid BCP-ALL patients show dismal prognosis although achieving an end-induction good MRD response.

 Fuente: Br J Haematol . 2019 Jul;186(2):263-268

Editorial: Blackwell Publishing Ltd

 Año de publicación: 2019

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/bjh.15887

ISSN: 0007-1048,1365-2141

Url de la publicación: https://www.doi.org/10.1111/bjh.15887

Autores/as

RIBERA, JORDI

GRANADA, ISABEL

MORGADES, MIREIA

VIVES, SUSANA

GENESCÁ, EULALIA

GONZÁLEZ, CELIA

NOMDEDEU, JOSEP

ESCODA, LOURDES

MONTESINOS PAU

MERCADAL, SANTIAGO

COLL, ROSA

GONZÁLEZ-CAMPOS, JOS É

ABELLA, EUGENIA

BARBA, PERE

TORMO, MAR

PEDREÑO, MARÍA

MARTÍNEZ- CARBALLEIRA, DANIEL

HERNÁNDEZ- RIVAS, JESÚS-MARÍA