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Stopping cannabis use benefits outcome in psychosis: findings from 10-year follow-up study in the PAFIP-cohort

Abstract: Objective: To examine the long-term (up to 10 years) patterns related to cannabis use in a sample of patients with first episode of psychosis (FEP) and the effect that consumption might have on clinical, functioning, and neurocognition at long-term. Methods: Cannabis use was described in 209 FEP patients. Patients were divided into three groups according to cannabis use: persistent users, ex-users, and never-users. Groups were longitudinally (baseline and 10-year follow-up) compared on clinical, functional, and cognitive variables. Results: Clinical differences at 10-year follow-up were observed between persistent cannabis users and the other two groups (ex-users and never-users), showing persistent users more severe symptoms (BPRS: x2 = 15.583, P ? 0.001; SAPS: x2 = 12.386, P = 0.002) and poorer functionality (DAS: x2 = 6.067, P = 0.048; GAF: x2 = 6.635, P = 0.033). Patients who stopped cannabis use prior to the reassessment showed a similar pattern to those who had never consumed. Conclusion: The use of cannabis could negatively affect the evolution of the psychotic disorder. Perhaps the negative effects caused by cannabis use could be reversed with the cessation of consumption. It is necessary to make an effort in the intervention toward an early withdrawal from the use of cannabis, since this could play an important role in the prognosis of the disease.

 Fuente: Acta Psychiatr Scand . 2019 Oct;140(4):349-359

Editorial: John Wiley & Sons

 Año de publicación: 2019

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.1111/acps.13081

ISSN: 0001-690X,1600-0447

Url de la publicación: https://www.doi.org/10.1111/acps.13081

Autores/as

Mª ESTHER SETIEN SUERO

NEERGAARD, K.

VICTOR ORTIZ GARCIA DE LA FOZ

OBDULIA MARTINEZ GARCIA

MARIA ROSA AYESA ARRIOLA