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Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients

Abstract: Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability of 209 MDR strains (Escherichia coli n = 106, Klebsiella pneumoniae n = 78, and Enterobacter spp. n = 25) isolated from rectal swabs in the first 48 hours before or after kidney (93 patients), liver (60 patients) or kidney/pancreas transplants (5 patients) were evaluated by using a microplate assay. Thirty-nine strains were isolated before transplant and 170 strains were isolated post-transplant. Overall, 16% of E. coli strains, 73% of K. pneumoniae strains and 4% Enterobacter strains showed moderate or strong biofilm production. Nine strains isolated from infection sites after transplantation were responsible of infections in the first month. Of these, 4 K. pneumoniae, 1 E. coli and 1 Enterobacter spp. strains isolated pre-transplant or post-transplant as colonizers caused infections in the post-transplant period. Our results suggest that in vitro biofilm formation could be an important factor for adhesion to intestine and colonization in MDR K. pneumoniae strains in SOT recipients, but this factor appears to be less important for MDR E. coli and Enterobacter spp.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Sci Rep 2019 Jun 20;9(1):8928

Editorial: Nature Publishing Group

 Año de publicación: 2019

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.1038/s41598-019-45060-y

ISSN: 2045-2322

Url de la publicación: https://www.doi.org/10.1038/s41598-019-45060-y

Autores/as

RAMOS-VIVAS, JOSÉ

CHAPARTEGUI-GONZÁLEZ, ITZIAR

FERNÁNDEZ-MARTÍNEZ, MARTA

GONZÁLEZ-RICO, CLAUDIA

FORTÚN, JESÚS

ESCUDERO, ROSA

MARCO, FRANCESC

LINARES, LAURA

MONTEJO, MIGUEL

ARANZAMENDI, MAITANE

MUÑOZ, PATRICIA

VALERIO, MARICELA

AGUADO, JOSE MARÍA

RESINO, ELENA

GRACIA AHUFINGER, IRENE

PAZ VEGA, AURORA

MARTÍNEZ-MARTÍNEZ, LUIS

THE ENTHERE STUDY GROUP