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Antimicrobial Susceptibility and Characterization of Resistance Mechanisms of Corynebacterium urealyticum Clinical Isolates

Abstract: Corynebacterium urealyticum is a non-diphtherial urease-producing clinically relevant corynebacterial, most frequently involved in urinary tract infections. Most of the C. urealyticum clinical isolates are frequently resistant to several antibiotics. We investigated the susceptibility of 40 C. urealyticum isolated in our institution during the period 2005-2017 to eight compounds representative of the main clinically relevant classes of antimicrobial agents. Antimicrobial susceptibility was determined by the Epsilometer test. Resistance genes were searched by PCR. All strains were susceptible to vancomycin whereas linezolid and rifampicin also showed good activity (MICs90 = 1 and 0.4 mg/L, respectively). Almost all isolates (39/40, 97.5%) were multidrug resistant. The highest resistance rate was observed for ampicillin (100%), followed by erythromycin (95%) and levofloxacin (95%). Ampicillin resistance was associated with the presence of the blaA gene, encoding a class A ?-lactamase. The two rifampicin-resistant strains showed point mutations driving amino acid replacements in conserved residues of RNA polymerase subunit ? (RpoB). Tetracycline resistance was due to an efflux-mediated mechanism. Thirty-nine PFGE patterns were identified among the 40 C. urealyticum, indicating that they were not clonally related, but producing sporadic infections. These findings raise the need of maintaining surveillance strategies among this multidrug resistant pathogen.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Antibiotics (Basel) . 2020 Jul 13;9(7):E404

Editorial: MDPI AG

 Año de publicación: 2020

Nº de páginas: 14

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/antibiotics9070404

ISSN: 2079-6382

Url de la publicación: https://www.doi.org/10.3390/antibiotics9070404

Autores/as

CHAPARTEGUI-GONZÁLEZ, ITZIAR

FERNÁNDEZ-MARTÍNEZ, MARTA

RODRÍGUEZ-FERNÁNDEZ, ANA

ROCHA, DANILO J. P.

AGUIAR, ERIC R. G. R.

PACHECO, LUIS G. C.

RAMOS-VIVAS, JOSÉ

CALVO, JORGE

MARTÍNEZ-MARTÍNEZ, LUIS