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Solid Lipid Particles for Lung Metastasis Treatment

Abstract: Solid lipid particles (SLPs) can sustainably encapsulate and release therapeutic agents over long periods, modifying their biodistribution, toxicity, and side effects. To date, no studies have been reported using SLPs loaded with doxorubicin chemotherapy for the treatment of metastatic cancer. This study characterizes the effect of doxorubicin-loaded carnauba wax particles in the treatment of lung metastatic malignant melanoma in vivo. Compared with the free drug, intravenously administrated doxorubicin-loaded SLPs significantly reduce the number of pulmonary metastatic foci in mice. In vitro kinetic studies show two distinctive drug release profiles. A first chemotherapy burst-release wave occurs during the first 5 h, which accounts for approximately 30% of the entrapped drug rapidly providing therapeutic concentrations. The second wave occurs after the arrival of the particles to the final destination in the lung. This release is sustained for long periods (>40 days), providing constant levels of chemotherapy in situ that trigger the inhibition of metastatic growth. Our findings suggest that the use of chemotherapy with loaded SLPs could substantially improve the effectiveness of the drug locally, reducing side effects while improving overall survival.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Pharmaceutics . 2021 Jan 13;13(1):93.

Editorial: MDPI

 Fecha de publicación: 01/01/2021

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

DOI: doi: 10.3390/pharmaceutics13010093.

ISSN: 1999-4923

Proyecto español: DTS19/00033

Url de la publicación: https://doi.org/10.3390/pharmaceutics13010093

Autores/as

LOURDES MARIA VALDIVIA FERNANDEZ

LORENA GARCIA HEVIA

BAÑOBRE LÓPEZ, MANUEL

GALLO, JUAN