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Abstract: Protein-based hybrid nanomaterials have recently emerged as promising platforms to fabricate tailored multifunctional biologics for biotechnological and biomedical applications. This work shows a simple, modular, and versatile strategy to design custom protein hybrid nanomaterials. This approach combines for the first time the engineering of a therapeutic protein module with the engineering of a nanomaterial-stabilizing module within the same molecule, resulting in a multifunctional hybrid nanocomposite unachievable through conventional material synthesis methodologies. As the first proof of concept, a multifunctional system was designed ad hoc for the therapeutic intervention and monitoring of myocardial fibrosis. This hybrid nanomaterial combines a designed Hsp90 inhibitory domain and a metal nanocluster stabilizing module resulting in a biologic drug labelled with a metal nanocluster. The engineered nanomaterial actively reduced myocardial fibrosis and heart hypertrophy in an animal model of cardiac remodeling. In addition to the therapeutic effect, the metal nanocluster allowed for in vitro, ex vivo, and in vivo detection and imaging of the fibrotic disease under study. This study evidences the potential of combining protein engineering and protein-directed nanomaterial engineering approaches to design custom nanomaterials as theranostic tools, opening up unexplored routes to date for the next generation of advanced nanomaterials in medicine.
Fuente: Chem. Sci., 2021,12, 2480-2487
Editorial: Royal Society of Chemistry
Año de publicación: 2021
Nº de páginas: 8
Tipo de publicación: Artículo de Revista
DOI: 10.1039/d0sc05215a
ISSN: 2041-6520,2041-6539
Proyecto español: PID2019-111649RB-I00; RTI2018-095214-B-I00; BIO2016-77367-C2-1-R; BIO2015-72124-EXP
Url de la publicación: https://pubs.rsc.org/en/content/articlelanding/2021/SC/D0SC05215A#!divAbstract
Consultar en UCrea Leer publicación
AIRES, ANTONIO
DAVID MAESTRO LAVIN
JORGE RUIZ DEL RIO
ANA ROSA PALANCA CUÑADO
LÓPEZ MARTÍNEZ, ELENA
LLARENA, IRANTZU
GERAKI, KALOTINA
SÁNCHEZ CANO, CARLOS
ANA VICTORIA VILLAR RAMOS
CORTAJARENA, AITZIBER L.
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