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Endothelial Progenitor Cells as a Potential Biomarker in Interstitial Lung Disease Associated with Rheumatoid Arthritis

Abstract: Interstitial lung disease (ILD) increases morbidity and mortality in patients with rheumatoid arthritis (RA). Although the pathogenesis of ILD associated with RA (RA-ILD+) remains poorly defined, vascular tissue is crucial in lung physiology. In this context, endothelial progenitor cells (EPC) are involved in endothelial tissue repair. However, little is known about their implication in RA-ILD+. Accordingly, we aimed to investigate the potential role of EPC related to endothelial damage in RA-ILD+. EPC quantification in peripheral blood from 80 individuals (20 RA-ILD+ patients, 25 RA-ILD? patients, 21 idiopathic pulmonary fibrosis (IPF) patients, and 14 healthy controls) was performed by flow cytometry. EPC were considered as CD34+, CD45low, CD309+ and CD133+. A significant increase in EPC frequency in RA-ILD+ patients, as well as in RA-ILD? and IPF patients, was found when compared with controls (p < 0.001, p = 0.02 and p < 0.001, respectively). RA-ILD+ patients exhibited a higher EPC frequency than the RA-ILD? ones (p = 0.003), but lower than IPF patients (p < 0.001). Our results suggest that EPC increase may represent a reparative compensatory mechanism in patients with RA-ILD+. The degree of EPC frequency may help to identify the presence of ILD in RA patients and to discriminate RA-ILD+ from IPF

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Journal of clinical medicine 2020, 9, 4098

Editorial: MDPI

 Año de publicación: 2020

Nº de páginas: 8

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm9124098

ISSN: 2077-0383

Url de la publicación: https://doi.org/10.3390/jcm9124098

Autores/as

VERÓNICA PULITO-CUETO

SARA REMUZGO-MARTÍNEZ

FERNANDA GENRE

VÍCTOR M. MORA-CUESTA

DAVID ITURBE FERNANDEZ

SONIA FERNÁNDEZ-ROZAS

BELÉN ATIENZA-MATEO

LETICIA LERA-GÓMEZ

PILAR ALONSO-LECUE

JAVIER RODRÍGUEZ-CARRIO

DIANA PRIETO-PEÑA

VIRGINIA PORTILLA

RICARDO BLANCO ALONSO

ALFONSO CORRALES

RAQUEL LÓPEZ-MEJÍAS