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Apremilast in refractory orogenital ulcers and other manifestations of Behçet's disease. A national multicentre study of 51 cases in clinical practice

Abstract: Objective. The objective of the present study was to assess the efficacy of apremilast (APR) in the management of refractory oral and/or genital ulcers in patients with Behçet?s disease (BD). Methods. National multicentre openlabel observational study on BD patients with recurrent oral and/or genital ulcers. In all cases orogenital ulcers were refractory to conventional therapy. APR was given and maintained at standard dose of 30 mg twice daily. The main outcome was the achievement of oral and/or genital ulcers remission. Efficacy of APR for other clinical manifestations was also evaluated. Results. We included 51 patients (35 women/16 men; mean age 44.7±13.2 years). Before APR, all patients had received several systemic conventional and/or biologic drugs. APR was initiated because of refractory oral (n=19) or genital (n=2) aphthous ulcers or both (n=30). Other manifestations found at APR onset were arthralgia/arthritis (n=16), folliculitis/pseudofolliculitis (n=14), erythema nodosum (n=3), furunculosis (n=2), paradoxical psoriasis induced by TNF-?-inhibitors (n=2), ileitis (n=2), deep venous thrombosis (n=2), leg ulcers (n=1), erythematosus and scaly skin lesions (n=1), fever (n=1), unilateral anterior uveitis (n=1) and neuro Behçet (n=1). After a mean follow-up of 8.5±6.9 months, most patients had experienced improvement of orogenital ulcers and prednisone dose had been successfully reduced or discontinued. APR also yielded improvement of some non-aphthous manifestations such as the cutaneous follicular and intestinal manifestations. However, the effect on musculoskeletal manifestations was variable. Conclusion. APR yielded a rapid and maintained improvement of refractory mucocutaneous ulcers of BD, even in patients refractory to several systemic drugs including biologic therapy.

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 Fuente: Clinical and Experimental Rheumatology 2020; 38 (Suppl. 127): S69-S75.

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2020

Nº de páginas: 7

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

B. ATIENZA-MATEO

J.L. MARTÍN-VARILLAS

J. GRAÑA

G. ESPINOSA

C. MORIANO

T. PÉREZ-SANDOVAL

M.D. GARCÍA-ARMARIO

I. CASTELLVÍ

J.A. ROMÁN-IVORRA

A. OLIVÉ

A. YBÁÑEZ

A. MARTINEZ-FERRER

J. NARVÁEZ

S. ROMERO-YUSTE

S. OJEDA

I. ROS

J. LORICERA

V. CALVO-RÍO

RICARDO BLANCO ALONSO