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Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

Abstract: ABSTRACT: Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Gómez-Acebo I., Dierssen-Sotos T., Palazuelos-Calderón C., Pérez-Gómez B., Amiano P., Guevara M., Molina A.J., Domingo L., Fernández-Ortiz M., Moreno V., Alguacil J., Fernández-Tardón G., Ibáñez J., Marcos-Gragera R., Diaz-Santos M., Alonso M.H., Alonso-Molero J., Castaño-Vinyals G., Palomo A.G., Ardanaz E., Molinuevo A., Aragonés N., Kogevinas M., Pollán M., Llorca J.,

 Fuente: Breast Cancer Research and Treatment. 2020; 181:667-678

Editorial: Kluwer Academic

 Año de publicación: 2020

Nº de páginas: 12

Tipo de publicación: Artículo de Revista

 DOI: 10.1007/s10549-020-05600-x

ISSN: 0167-6806,1573-7217

Url de la publicación: https://doi.org/10.1007/s10549-020-05600-x

Autores/as

CAMILO PALAZUELOS CALDERON

PÉREZ-GÓMEZ, BEATRIZ

AMIANO, INÉS

GUEVARA, MARCELA

MOLINA, ANTONIO J.

DOMINGO, LAIA

MARIA FERNANDEZ ORTIZ

MORENO, VICTOR

ALGUACIL, JUAN

FERNÁNDEZ-TARDÓN, GUILLERMO

IBAÑEZ, JOSEFA

MARCOS-GRAGERA, MARCOS

DIAZ-SANTOS, MARIAN

HENAR ALONSO, M.

CASTAÑO-VINYALS, GEMMA