Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Disease activity influences cardiovascular risk reclassification based on carotid ultrasound in patients with psoriatic arthritis

Abstract: ABSTRACT: Objective. Because the addition of carotid ultrasound (US) into composite cardiovascular (CV) risk scores has been found effective for identifying patients with inflammatory arthritis and high CV risk, we aimed to determine whether its use would facilitate the reclassification of patients with psoriatic arthritis (PsA) into the very high Systematic Coronary Risk Evaluation (SCORE) risk category and whether this might be related to disease features. Methods. This was a cross-sectional study involving 206 patients who fulfilled ClASsification for Psoriatic ARthritis criteria for PsA, and 179 controls. We assessed lipid profile, SCORE, disease activity measurements, and the presence of carotid plaques and carotid intima-media thickness by ultrasonography. A multivariable regression analysis, adjusted for classic CV risk factors, was performed to evaluate whether the risk of reclassification could be explained by disease-related features and to assess the most parsimonious combination of risk reclassification predictors. Results. Forty-seven percent of patients were reclassified into a very high SCORE risk category after carotid US compared to 26% of controls (p < 0.001). Patients included in the low SCORE risk category were those who were more commonly reclassified (30% vs 14%, p = 0.002). The Disease Activity Index for PsA (DAPSA) score was associated with reclassification (? 1.10, 95% CI 1.02?1.19; p = 0.019) after adjusting for age and traditional CV risk factors. A model containing SCORE plus age, statin use, and DAPSA score yielded the highest discriminatory accuracy compared to the SCORE-alone model (area under the receiver-operating characteristic curve 0.863, 95% CI 0.789?0.936 vs 0.716, 95% CI 0.668?0.764; p < 0.001). Conclusion. Patients with PsA are more frequently reclassified into the very high SCORE risk category following carotid US assessment than controls. This was independently explained by the disease activity.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: The Journal of Rheumatology September. 2020; 47(9):1344-1353

Editorial: The Journal of Rheumatology Publishing Company Limited

 Año de publicación: 2020

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

 DOI: 10.3899/jrheum.190729

ISSN: 0315-162X

Url de la publicación: https://doi.org/10.3899/jrheum.190729

Autores/as

PALMOU-FONTANA, NATALIA

MARTÍNEZ-LOPEZ, DAVID

CORRALES,ALFONSO

JAVIER RUEDA GOTOR

GENRE, FERNANDA

QUEVEDO-ABELEDO, JUAN C.

PORTILLA-GONZÁLEZ, VIRGINIA

RICARDO BLANCO ALONSO