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Cranial and extracranial giant cell arteritis share similar HLA-DRB1 association

Abstract: Objective: To determine whether giant cell arteritis (GCA) patients with the typical pattern of cranial ischemic manifestations and those with the extracranial large-vessel-vasculitis (LVV)-GCA phenotype exhibit different HLA-DRB1 association. Methods: 178 biopsy-proven GCA patients who had cranial ischemic features but no LVV manifestations, 100 patients with LVV-GCA without cranial ischemic manifestations and 486 ethnically matched healthy controls were recruited. All patients and controls were Spanish of European ancestry. We compared HLA-DRB1 phenotype frequencies between the three groups. Results: Both GCA subgroups had well-differentiated clinical features. Patients with LVV-GCA were younger (68.0 § 10.0 years versus 74.0 §10.4 years; p < 0.01) and presented more commonly with polymyalgia rheumatica symptoms (81% versus 39.3%; p < 0.01) than those with the classic cranial GCA phenotype. HLADRB1* 04 phenotype frequency was significantly increased in patients with classic cranial GCA compared to controls (42.1% versus 23.5%, respectively; p < 0.01; odds ratio-OR [95% confidence interval-CI] = 2.38 [1.623.47]). This association was mainly due to the HLA-DRB1*04:01 allele (20.8% versus 5.3%, respectively; p < 0.01; OR [95% CI] = 4.64 [2.638.26]). HLA-DRB1*04 association was also observed in LVV-GCA patients when compared to controls (46.0% versus 23.5%, respectively; p < 0.01; OR [95% CI] = 2.78 [1.734.44]).

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Seminars in Arthritis and Rheumatism 50 (2020) 897901

Editorial: Elsevier

 Año de publicación: 2020

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

 DOI: 10.1016/j.semarthrit.2020.07.004

ISSN: 0049-0172,1532-866X

Url de la publicación: https://doi.org/10.1016/j.semarthrit.2020.07.004

Autores/as

DIANA PRIETO-PEÑA

SARA REMUZGO-MARTÍNEZ

JAVIER GONZALO OCEJO-VINYALS

BELÉN ATIENZA-MATEO

ALEJANDRO MUÑOZ-JIMÉNEZ

FRANCISCO ORTIZ-SANJUAN

SUSANA ROMERO-YUSTE

CLARA MORIANO

EVA GALÍNDEZ-AGIRREGOIKOA

JOSÉ A. MIRANDA-FILLOY

RICARDO BLANCO ALONSO

ORESTE GUALILLO

JAVIER MARTÍN

SANTOS CASTAÑEDA

RAQUEL LÓPEZ-MEJÍAS