Estamos realizando la búsqueda. Por favor, espere...
Abstract: Objective: To determine whether giant cell arteritis (GCA) patients with the typical pattern of cranial ischemic
manifestations and those with the extracranial large-vessel-vasculitis (LVV)-GCA phenotype exhibit different
Methods: 178 biopsy-proven GCA patients who had cranial ischemic features but no LVV manifestations, 100
patients with LVV-GCA without cranial ischemic manifestations and 486 ethnically matched healthy controls
were recruited. All patients and controls were Spanish of European ancestry. We compared HLA-DRB1 phenotype
frequencies between the three groups.
Results: Both GCA subgroups had well-differentiated clinical features. Patients with LVV-GCA were younger
(68.0 § 10.0 years versus 74.0 §10.4 years; p < 0.01) and presented more commonly with polymyalgia rheumatica
symptoms (81% versus 39.3%; p < 0.01) than those with the classic cranial GCA phenotype. HLADRB1*
04 phenotype frequency was significantly increased in patients with classic cranial GCA compared to
controls (42.1% versus 23.5%, respectively; p < 0.01; odds ratio-OR [95% confidence interval-CI] = 2.38
[1.623.47]). This association was mainly due to the HLA-DRB1*04:01 allele (20.8% versus 5.3%, respectively;
p < 0.01; OR [95% CI] = 4.64 [2.638.26]). HLA-DRB1*04 association was also observed in LVV-GCA patients
when compared to controls (46.0% versus 23.5%, respectively; p < 0.01; OR [95% CI] = 2.78 [1.734.44]).
Fuente: Seminars in Arthritis and Rheumatism 50 (2020) 897901
Año de publicación: 2020
Nº de páginas: 5
Tipo de publicación: Artículo de Revista
Url de la publicación: https://doi.org/10.1016/j.semarthrit.2020.07.004
JAVIER GONZALO OCEJO-VINYALS
JOSÉ A. MIRANDA-FILLOY
RICARDO BLANCO ALONSO
MIGUEL ANGEL GONZALEZ-GAY MANTECON