Cytokines signaling pathway genes represent a key component of the genetic network implicated in the pathogenesis of immunoglobulin-A vasculitis (IgAV), an inflammatory vascular pathology. Interleukin (IL)17A is described as a genetic risk locus for some autoimmune diseases, such as giant cell arteritis and spondyloarthritis. Accordingly, we aimed to determine the potential influence of IL17A on the pathogenesis of IgAV.
Five IL17A tag polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909), which cover the major variability of this gene, were genotyped in 360 Caucasian patients with IgAV and 1,003 sex and ethnically matched healthy controls using TaqMan probes.
No statistically significant differences between patients with IgAV and healthy controls were observed when each IL17A genetic variant was analysed independently. Similarly, no statistically significant differences between patients with IgAV and healthy controls were found when the five IL17A polymorphisms were evaluated combined conforming haplotypes. In addition, there were no statistically significant differences in genotype, allele and haplotype frequencies of IL17A when patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations.
Our results do not support an influence of IL17A on the pathogenesis of IgAV.
Fuente: Clinical and Experimental Rheumatology 2020 Vol.38, N°2 ,Suppl.124
Editorial: Clinical and Experimental Rheumatology
Año de publicación: 2020
Nº de páginas: 5
Tipo de publicación: Artículo de Revista
FRANCISCO JAVIER LLORCA DIAZ
LEONARDO, MARÍA TERESA
MARIA JESUS CABERO PEREZ
LUIS MARTIN PENAGOS
MIRANDA-FILLOY, JOSÉ A.
NAVAS PAREJO, ANTONIO
SÁNCHEZ PÉREZ, JAVIER
ARGILA, DIEGO DE
LEÓN LUQUE, MANUEL
BLANCO-MADRIGAL, JUAN MARÍA
RICARDO BLANCO ALONSO
MIGUEL ANGEL GONZALEZ-GAY MANTECON