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Influence of IL17A gene on the pathogenesis of immunoglobulin-A vasculitis

Abstract: Objetives: Cytokines signaling pathway genes represent a key component of the genetic network implicated in the pathogenesis of immunoglobulin-A vasculitis (IgAV), an inflammatory vascular pathology. Interleukin (IL)17A is described as a genetic risk locus for some autoimmune diseases, such as giant cell arteritis and spondyloarthritis. Accordingly, we aimed to determine the potential influence of IL17A on the pathogenesis of IgAV. Methods: Five IL17A tag polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909), which cover the major variability of this gene, were genotyped in 360 Caucasian patients with IgAV and 1,003 sex and ethnically matched healthy controls using TaqMan probes. Results: No statistically significant differences between patients with IgAV and healthy controls were observed when each IL17A genetic variant was analysed independently. Similarly, no statistically significant differences between patients with IgAV and healthy controls were found when the five IL17A polymorphisms were evaluated combined conforming haplotypes. In addition, there were no statistically significant differences in genotype, allele and haplotype frequencies of IL17A when patients with IgAV were stratified according to the age at disease onset or to the presence/absence of gastrointestinal or renal manifestations. Conclusions: Our results do not support an influence of IL17A on the pathogenesis of IgAV.

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 Fuente: Clinical and Experimental Rheumatology 2020 Vol.38, N°2 ,Suppl.124

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2020

Nº de páginas: 5

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

LÓPEZ-MEJÍAS, RAQUEL

GENRE, FERNANDA

REMUZGO-MARTÍNEZ, SARA

PULITO-CUETO, VERÓNICA

SEVILLA-PÉREZ, BELÉN

ORTEGO-CENTENO, NORBERTO

MIJARES, VERÓNICA

LERA-GÓMEZ, LETICIA

LEONARDO, MARÍA TERESA

PEÑALBA, ANA

LUIS MARTIN PENAGOS

MIRANDA-FILLOY, JOSÉ A.

NAVAS PAREJO, ANTONIO

SÁNCHEZ PÉREZ, JAVIER

ARGILA, DIEGO DE

RUBIO, ESTEBAN

LEÓN LUQUE, MANUEL

BLANCO-MADRIGAL, JUAN MARÍA

GALÍNDEZ-AGIRREGOIKOA, EVA

MARTÍN, JAVIER

RICARDO BLANCO ALONSO

CASTAÑEDA, SANTOS