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Rituximab in the treatment of interstitial lung disease associated with autoimmune diseases: experience from a single referral center and literature review

Abstract: ABSTRACT: In the present study, we aimed to report our experience with rituximab (RTX) in the treatment of patients with ILD associated with AD (AD-ILD) at a single center. For this purpose, clinical characteristics, radiological findings, and pulmonary function tests (PFTs) of RTX-treated AD-ILD-patients seen from May 2016 until March 2020 at a referral center for individuals with ILD were retrospectively reviewed. Additionally, an updated literature review was conducted. A total of 26 patients (mean age 58.3 ± 11.1 years at ILD diagnosis) was included. The most common ADs related to ILD were systemic sclerosis, idiopathic inflammatory myositis (including anti-synthetase syndrome) and rheumatoid arthritis. Non-specific interstitial pneumonia (n = 12) and usual interstitial pneumonia (n = 11) were the predominant radiological patterns. The sustained improvement in PFTs was observed from the start of RTX, with a statistically significant increase in DLCO from basal to one year after RTX (mean + 4.2%, p = 0.024). Overall, there were no differences when comparing PFT outcome according to the radiological pattern or the specific type of AD. In conclusion, RTX constitutes a good therapeutic option to preserve lung function in patients with AD-ILD, regardless of the radiological pattern or the underlying AD.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Journal of clinical medicine 2020, 9(10), 3070

Editorial: MDPI

 Fecha de publicación: 23/09/2020

Nº de páginas: 19

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm9103070

ISSN: 2077-0383

Url de la publicación: https://doi.org/10.3390/jcm9103070

Autores/as

ATIENZA-MATEO, BELÉN

REMUZGO-MARTÍNEZ, SARA

PRIETO-PEÑA, DIANA

MORA CUESTA, VICTOR MANUEL

DAVID ITURBE FERNANDEZ

SÁNCHEZ-BILBAO, LARA

CORRALES, ALFONSO

BLANCO RODRÍGUEZ, GERARDO