Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Prevalence of hospital PCR-confirmed COVID-19 cases in patients with chronic inflammatory and autoimmune rheumatic diseases

Abstract: Background The susceptibility of patients with rheumatic diseases and the risks or benefits of immunosuppressive therapies for COVID-19 are unknown. Methods We performed a retrospective study with patients under follow-up in rheumatology departments from seven hospitals in Spain. We matched updated databases of rheumatology patients with severe acute respiratory syndrome coronavirus 2-positive PCR tests performed in the hospital to the same reference populations. Rates of PCR+ confirmed COVID-19 were compared among groups. Results Patients with chronic inflammatory diseases had 1.32-fold higher prevalence of hospital PCR+ COVID-19 than the reference population (0.76% vs 0.58%). Patients with systemic autoimmune or immune-mediated disease (AI/IMID) showed a significant increase, whereas patients with inflammatory arthritis (IA) or systemic lupus erythematosus did not. COVID-19 cases in some but not all diagnostic groups had older ages than cases in the reference population. Patients with IA on targeted-synthetic or biological disease-modifying antirheumatic drugs (DMARDs), but not those on conventional-synthetic DMARDs, had a greater prevalence despite a similar age distribution. Conclusion Patients with AI/IMID show a variable risk of hospital-diagnosed COVID-19. Interplay of ageing, therapies and disease-specific factors seem to contribute. These data provide a basis to improve preventive recommendations to rheumatic patients and to analyse the specific factors involved in COVID-19 susceptibility.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Annals of the Rheumatic Diseases 2020;79:1170-1173

Editorial: BMJ Publishing Group

 Año de publicación: 2020

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1136/annrheumdis-2020-217763

ISSN: 0003-4967,1468-2060

Url de la publicación: http://dx.doi.org/10.1136/annrheumdis-2020-217763

Autores/as

JOSE L PABLOS

LYDIA ABASOLO

JOSE M ALVARO-GRACIA

FRANCISCO J BLANCO

RICARDO BLANCO ALONSO

ISABEL CASTREJÓN

DAVID FERNANDEZ-FERNANDEZ

BENJAMÍN FERNANDEZ-GUTIÉRREZ

MARÍA GALINDO-IZQUIERDO

SARA MANRIQUE-ARIJA

NATALIA MENA VÁZQUEZ

ANTONIO MERA VARELA

MIRIAM RETUERTO

ALVARO SEIJAS-LOPEZ

DAVID MARTINEZ-LOPEZ